Principal Scientist

2 months ago

Vancouver, British Columbia, Canada AbCellera Full time
About the Role

We are seeking a highly motivated Principal Scientist to join our team at AbCellera, a global company that discovers and develops antibody-based medicines. As a key member of our research team, you will contribute to the assessment and development of antibody-based oncology drug candidates, driving our mission to bring innovative medicines to patients.

Key Responsibilities
  • Lead internal preclinical in vivo oncology models to support oncology programs
  • Design, support, and interpret pharmacology studies to generate in vivo proof-of-concept and build confidence in selection of molecules for clinical development
  • Collaborate with in vitro biology, protein engineering, and pharmacokinetics scientists, as well as external CROs and collaborators, to execute efficient PK/PD studies to identify lead molecules and advance programs to human trials
  • Mentor team members in laboratory techniques related to tumour xenograft models
  • Report findings to internal program teams and partners to support data-driven decisions
  • Evaluate available preclinical and clinical data sets to build testable biological hypotheses for oncology targets and then preclinically assess those hypotheses
  • Develop and oversee supporting assays to assess target modulation and downstream effects at the cellular, protein, and gene level
Requirements
  • 10+ years of hands-on experience in oncology, immuno-oncology, and biologics drug development
  • PhD in pharmacology, immunology, or related field, plus 10+ years of experience in a biopharmaceutical industry setting; or a MSc and 15 years of relevant experience
  • Proven interpersonal skills and ability to create value on cross-functional teams
  • Genuine curiosity and interest in discussing innovative ideas in a highly collaborative and fast-paced environment
  • Ability to communicate scientific and/or technical concepts with an emphasis on application
  • Capacity to independently identify project needs and follow up with constructing and implementing solutions
  • Enjoyment of teamwork and building data sets that help predict the success of therapies
What We Offer

AbCellera's hiring range for this role is CAD $141,600 - $177,000 annually, commensurate with your education and job-related knowledge, skills, and experience. In addition to base salary, we offer equity, annual bonus dependent on team and company performance, and a 6% (non-match) RRSP contribution.

You will have a CAD $1,500 annual Active Lifestyle Allowance, annual vacation, opportunity for flexible work arrangements, professional development opportunities, and comprehensive health benefits. Scientific and technical mentorship is a priority. And you'll find we prioritize team building and connections across AbCellera.

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