Research Lab Tech I 3 Days Left

3 weeks ago

Ottawa, Ontario, Canada University of Massachusetts Medical School Full time
Overview

GENERAL SUMMARY OF POSITION:

Under the supervision of the Principal Investigator or designee, the Research Laboratory Technician I performs animal colony management and routine laboratory maintenance.

Responsibilities

MAJOR RESPONSIBILITIES:

- Perform a variety of laboratory experiments using both routine and special techniques and methods.
- Perform animal colony management such as weaning, ear punching, cage changing, and RO bleeding.
- Record results, organize data, and perform basic computations.
- Maintain laboratory supplies and equipment.
- Comply with all safety standards.
- Conduct laboratory procedures and experiments as directed by the Principal Investigator, which includes tissue culture techniques, tissue staining (immunohistochemistry), and molecular biology techniques (protein isolation and Western blotting).
- Order laboratory supplies as needed and maintain accurate records and files of purchases.
- Perform other duties as required.

Qualifications

REQUIRED QUALIFICATIONS:

- Bachelor's degree in Biological Science or an Associate's degree in Biological Sciences and two years of experience, or equivalent.
- Knowledge of Microsoft Office products.
- Ability to perform duties independently.
- Judgment and action skills required to solve commonly encountered problems.

SUPERVISION RECEIVED: Under the supervision of the Principal Investigator or designee.

SUPERVISION EXERCISED: None.

ENVIRONMENTAL WORKING CONDITIONS:

Wet chemistry laboratory, and may require appropriate contact with biohazards, radionuclides, toxins, animals, and human specimens.

Additional Information

Varanasi Lab in the Division of Innate Immunity

Studying tissue-specific interactions between metabolism and immunity.

Research Focus: Understanding the molecular mechanisms of tissue-specific immune responses.

- Metabolic/differentiation states of T cells.
- How metabolic tissue states contribute to T cell responses.
- How the gut microbiome and its metabolites affect T cell responses.

CD8+ T cells exhibit a remarkable capacity to infiltrate diverse tissues throughout the body. Given that every tissue is physiologically and metabolically distinct, it is important to understand how tissue-infiltrating T cells metabolically adapt in a tissue-specific manner to maintain optimal responses and how these adaptations are dysregulated in disease. This information can be further used to manipulate T cell responses to manage a variety of diseases where T cell responses are involved. Therefore, a major goal of the lab is to understand how different T cells metabolically adapt to different tissue microenvironments during homeostatic and disease states such as tumor, autoimmunity, or chronic virus infection.

Learn more here: https://www.umassmed.edu/varanasilab/

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