Research Scientist

3 weeks ago

Toronto, Canada University Health Network Full time

**Position: Research Scientist**
**Location: MaRS Centre, Toronto**
**Department: Drug Discovery Program**
**Reports To: Scientific Advisor**
**Salary: Commensurate with level of experience**

**Hours: 35 hours/week**
**Job Type: On-site**
**Status: Full-Time, Permanent**

OICR is Ontario’s cancer research institute. We bring together people from across the province and around the world to improve the lives of everyone affected by cancer. We take on the biggest challenges in cancer research and deliver real-world solutions to find cancer earlier and treat it more effectively. We are committed to helping people living with cancer, as well as future generations, live longer and healthier lives.

Launched in December 2005, OICR is an independent institute funded by the Government of Ontario through the Ministry of Colleges and Universities.

**Position responsibilities include**:

- Data mine large scale datasets to identify potential novel anti-cancer targets.
- Validate oncology drug discovery targets using established genetic techniques (siRNA, shRNA, CRISPR) with associated rescue experiments.
- Develop and conduct relevant cell-based assays to screen small molecule hits and support SAR to move projects from screening, through hit assessment, and into lead generation and optimization.
- Maintain a knowledge of new cell based assays and methods that impact the drug discovery process.
- Collaborate effectively with the biology team and with medicinal chemists.
- Mentor undergraduate and graduate students and assist with their technical training.
- Work effectively under pressure and tight timelines.
- Communicate effectively with internal and external collaborators.

**Qualifications**:

- PhD in Biochemistry or Cell Biology with experience in drug discovery or recognized equivalent.
- Experience in the development / execution of small molecule cell based screens.
- Experience in the development of cell-based target engagement and functional assays to support medicinal chemistry efforts.
- Experience in the validation of novel anti-cancer targets using genetic techniques.
- Familiarity with the drug discovery processes and timelines in general.
- Knowledge of cancer biology and related signal transduction pathways.
- Great team player with excellent interpersonal and communication skills.
- Highly motivated self-starter who enjoys an element of ambiguity and is willing to adapt to a changing environment.

To learn more about working at OICR, visit our career page.

**CLOSING DATE: Until Filled**
- The Ontario Institute for Cancer Research thanks all applicants. However, only those under consideration will be contacted._

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