Vice President Clinical, Oncology

3 weeks ago

Montréal, Canada Thryv Therapeutics Inc. Full time

Senior Director/Vice President Clinical, Oncology Position
Thryv Therapeutics Inc. is a privately owned company based in Montreal, Quebec, Canada. We
have been pioneering a precision medicine approach to treat Long QT Syndrome via SGK1
inhibition since 2019 and have since evolved our portfolio to include the treatment of resistant
and rare cancers.
OPPORTUNITY SUMMARY
The Senior Director or Vice President Clinical, Oncology will report to the Chief Medical Officer
and will be responsible for overseeing the strategic and clinical development of the Thryv
Therapeutics’ Oncology Program in collaboration with Clinical Operations, Regulatory, and
Translational Research.
KEY RESPONSIBILITIES
- Lead clinical and strategic efforts in oncology to establish safety, PK/PD, and dose

justification, to establish proof of concepts, and ultimately clinical development strategy
to secure regulatory approvals.
- Work with teams to identify best options, evaluate indications and designs and propose

scenarios and recommendations to seek Executive Committee and Board of Directors
approval.
- Develop and review FDA documents (e.g., briefing documents, IND, NDA) and study

related documents (e.g., Investigator Brochure, CRFs, protocol, CSRs, etc.)
- Provide clinical regulatory science research expertise, especially regarding study design,

data interpretation, and Safety Review Committee input.
- Direct staff to ensure efficiency for day-to-day operations and to meet the goals of the

program.
- Contribute to the cross-functional development team from the clinical and scientific

perspective to achieve corporate goals.
QUALIFICATIONS
EDUCATION AND WORK EXPERIENCE
- MD or MD/PhD degree with 6+ years experience in clinical oncology drug development;
experience in immuno-oncology is an advantage.
TECHNICAL KNOWLEDGE AND SKILLS
- Demonstrated clinical research experience in early stage and late-stage development

including first-in human trials, proof of concept trials and registration-directed trials;
experience with implementation and analysis of pharmacodynamic and potential
predictive biomarkers in clinical trials is an advantage.
- Experience with strategic alliances and/or collaborations
- Proven ability to provide solutions to a variety of technical problems of moderate scope

and difficult complexity.
- Excellent written and verbal communication skills, including ability to effectively present

information and respond to questions from project teams, external vendors, investors,
investigators, and KOLs.
- NON-TECHNICAL SKILLS AND COMPETENCIES
- Exudes the highest level of integrity and an acute sense of ethics.
- Operates with a sense of urgency and perseverance to achieve results.
- Superior problem solving, conflict management and interpersonal skills.
- Ability and enthusiasm to work in a cross-functional team environment.
- Superior organizational skills and the ability to multi-task and prioritize competing

assignments.
- Excellent oral/written communication, interpersonal, organizational and presentation

skills
- Proactive and self-motivated with the ability to work independently with mínimal

supervision.
- Ability to work under pressure to meet deadlines.
- Strong leadership qualities
- Ability to travel up to 20% of the time.

**BENEFITS**:
Thryv Therapeutics offers a group benefits plan with Manulife Insurance. The plan includes the
following benefits: health, dental, travel, virtual medicine, and EAP. All permanent full-time
employees are eligible for this plan after 90 days of work at Thryv Therapeutics.
EQUAL OPPORTUNITY WORKPLACE
Thryv Therapeutics is proud to be an equal opportunity. We are committed to equal employment
opportunity regardless of race, colour, religion, sex, sexual orientation, gender identity, age,
national origin, disability, and any other characteristic protected by law.
APPLY
Directeur(trice) Principal(e)/VP, Oncologie Clinique
Thérapeutiques Thryv Inc. est une entreprise privée basée à Montréal, Québec, Canada. Nous
sommes les pionniers d'une approche de médecine de précision pour traiter le syndrome du QT

long par l'inhibition de SGK1 depuis 2019 et avons depuis évolué notre portefeuille pour inclure
le traitement de cancers rares et résistants.
RÉSUMÉ DE L'OPPORTUNITÉ
Le Directeur(trice) principal(e) ou le Vice-président(e), Oncologie clinique relèvera du Directeur
médical en chef et sera responsable de la supervision du développement stratégique et clinique
du programme d'oncologie de Thérapeutiques Thryv en collaboration avec les opérations
cliniques, la réglementation et la recherche translationnelle.
RESPONSABILITÉS PRINCIPALES
- Diriger les efforts cliniques et stratégiques en oncologie pour établir la sécurité, la

justification de la dose et les PK/PD, pour établir des preuves de concept ainsi que la
stratégie de développement clinique pour obtenir les approbations réglementaires
- Travailler avec les équipes pour identifier les meilleures op

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