Research Scientist 1, Cmc, Process Chemistry
2 weeks ago
**Who We Are**:
**At Xenon Pharmaceuticals (NASDAQ**: XENE), we are committed to providing a brighter future for patients suffering from neurological disorders. Our employees are smart, passionate, dedicated, and driven by their incredibly important work to discover, develop, and deliver innovative medicines for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.
**What We Do**:
We are advancing an exciting pipeline of neurology-focused therapies, with a focus on commercializing novel treatments for epilepsy. Building upon the positive results and compelling data from our XEN1101 Phase 2b “X-TOLE” study in adult patients with focal epilepsy, our XEN1101 Phase 3 program includes studies in adult patients with focal onset seizures and primary generalized tonic clonic seizures. In addition, XEN1101 is being evaluated as a treatment for major depressive disorder in both a company-sponsored Phase 2 clinical trial, as well as an investigator-led proof-of-concept study. Xenon's proprietary, pediatric formulation of ezogabine, XEN496, is being studied in a Phase 3 clinical trial in young patients with KCNQ2-DEE, a rare and severe form of childhood epilepsy. We are also proud of the leading-edge science coming out of our discovery labs, where many innovative, early-stage research programs are underway. In addition to these proprietary programs, our pipeline includes clinical-stage partnered programs with valued collaborators. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.
**About the Role**:
**RESPONSIBILITIES**:
- Develop processes for scaling-up compounds from Xenon’s internal pipeline.
- Properly document the scale up processes in an electronic notebook system.
- Synthesize impurity standards and metabolites, as required.
- Perform basic salt screening and polymorph screening activities as needed.
- Work with CMC Drug Substance Managers to transfer processes and procedures to outsourced contract development and manufacturing organizations (CDMOs)
- Collaborate with colleagues in the CMC Drug Product and Drug Substance subgroups, such that relevant deliverables are optimal for use in, or as, GLP material.
- Participate in CDMO technology transfers and site visits as required.
- Conduct general laboratory inventory, maintenance, and monitoring.
- Organize and file internal data, protocols, and reports.
- Keep up to date and detailed records of experiments and data analysis within an Electronic Lab Notebook system. Ensure experiments are counter-signed on a monthly basis.
- Ensure the laboratory environment is safe and well-organized; follow and keep up to date with Health & Safety policies and procedures.
- Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any.
- Other duties as assigned.
**QUALIFICATIONS**:
- PhD (0-2 years’ experience) or MSc (3-5 years’ experience) in synthetic organic chemistry with hands-on synthetic laboratory experience.
- Good knowledge of analytical techniques including compound purification methods and interpretation of analytical data such as NMR, IR, HPLC, LCMS.
- Excellent written and oral communication skills, including the ability to communicate with scientific and non-scientific personnel.
- Maintain a high degree of awareness and commitment to providing accurate, high-quality work.
- Good organizational skills and the ability to manage multiple competing priorities.
- Strong interpersonal and team skills to work both independently and collaboratively as part of a multidisciplinary team.
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