Development of Dna-based Biosensors

2 weeks ago

Sherbrooke, Canada Université de Sherbrooke Full time

**Development of DNA-based biosensors / Développement de biocapteurs à base d'ADN**:

- Réf
- **ABG-109616**
- Sujet de Thèse- 17/01/2023- Financement public/privé- Université de Sherbrooke- Lieu de travail- Sherbrooke - Canada- Intitulé du sujet- Development of DNA-based biosensors / Développement de biocapteurs à base d'ADN- Champs scientifiques- Chimie
- Biochimie
- Biotechnologie
- Mots clés- Biosensors, biophysics, electrochemistry, fluorescence, calorimetry, plasmonics, organic chemistry**Description du sujet**:
As a doctoral student, you will work jointly with interns, M.Sc., Ph.D. and postdoc in the study of DNA with a combination of characterization techniques in solution and on substrates. These experiments will provide information on DNA affinity, as well as sensitivity and stability. Your research project will provide you with training and development in:

- Solution based techniques (fluorescence, UV-vis, calorimetry, etc.)
- Surface techniques (SPR and electrochemistry)
- Biomolecule modification, characterization and purification
- Programming, computational chemistry and machine learning

For more details on current research, publications and members of the group, please consult the laboratory's website:
En tant qu’étudiant au doctorat, vous travaillerez conjointement avec des stagiaires, M.Sc., Ph.D. et postdoc dans l'étude de séquences d'ADN avec une combinaison de techniques de caractérisation en solution et sur substrats. Les expériences réalisées fourniront de l’information sur l'affinité, leur sensibilité et leur stabilité. Votre projet de recherche vous fournira une formation et un perfectionnement sur:

- Techniques en solution (fluorescence, UV-vis, calorimétrie, etc.)
- Techniques de surface (SPR et électrochimie)
- Techniques de modification de biomolécules
- Programmation, chimie computationnelle et apprentissage automatique

Pour plus de détails sur les recherches en cours, les publications et les membres du groupe, veuillez consulter le site du laboratoire:
**Prise de fonction**:

- 01/09/2023**Nature du financement**:

- Financement public/privé**Précisions sur le financement**:
**Présentation établissement et labo d'accueil**:

- Université de SherbrookeLab work will be conducted under the mentorship of professor Philippe Dauphin Ducharme in the Chemistry Department of Université de Sherbrooke or at the Pharmacology institute of the Université de Sherbrooke (Québec), Canada, although visits or internships could be envisioned with our collaborators to complement training.

The Université de Sherbrooke is ranked at the 14th place in Canada based on the research income, making it a well known establishement in Canada for its excellence in research and the high premium put on teaching and mentoring by professors. The student will have access to a plethora of state-of-the-art characterization techniques in the fields electrochemistry, spectroscopy, organic chemistry and inorganic chemistry (potentiostats, magnetic resonance imaging, fluorimeter, calorimeter, circular dichroism, NMR, LC-MS, etc.).

The Université de Sherbrooke hosts over 36000 students yearly and is located ~1h30 South
- East of Montreal in the beautiful region of Cantons de l’Est. This area offers some of the best outdoor activities (cycling, hiking, skiing, etc.) so that you can maintain a healthy work-life balance. As a result, and according to Maclean’s, Université de Sherbrooke’s student satisfaction has been ranking at the top among all Canadian institutions for the last five years among all other Canadian institutions.Les travaux de laboratoire seront effectués sous la supervision du professeur Philippe Dauphin Ducharme au département de chimie ou à l'Institut de pharmacologie de l'Université de Sherbrooke (Québec), Canada, bien que des visites ou des stages puissent être envisagés avec nos collaborateurs pour bonifier la formation.

L'Université de Sherbrooke se classe au 14e rang national selon les revenus de la recherche, ce qui en fait un établissement reconnu au Canada pour son excellence en recherche et la haute qualité de l'enseignement et de mentorat offert par les professeurs. L'étudiant aura accès à une large infrastructure de techniques de caractérisation de pointe dans les domaines de l'électrochimie, de la spectroscopie, de la chimie organique et inorganique (potentiostats, imagerie par résonance magnétique, spectrofluorimètre, calorimètre, dichroïsme circulaire, RMN, LC-MS, etc.).

L’Université de Sherbrooke compte plus de 36000 étudiantes et étudiants et est située à ~1h30 au sud-est de Montréal, dans la belle région des Cantons de l’Est offrant le meilleur de l’expérience québécoise. En étant localisé à Sherbrooke, vous pourrez vous évadez dans la nature (vélo, randonnées, ski, etc.) ou encore bénéficier de nombreuses activités urbaines vous offrant une qualité de vie hors pair. Selon le palmarès M

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