Research Associate

3 weeks ago

Mississauga, Canada Microbix Biosystems Inc. Full time

**R&D Position (6-month contract)**:
**Research Associate - Process Development & Engineering**

The current available 6-month, full-time position (contract) is for a motivated and self-directed Research Associate to join the Process Development & Engineering team within the Department of Research and Development.

This position reports to Manager - Process Development & Engineering.

**Scope of work**:

- Development of qPCR workflow for virus quantitation_
- Performing nucleic acid extraction and purification from upstream and downstream in-process samples
- Development and execution of qPCR workflow for amplifying target virus
- Interpretation of amplification plots and determining virus concentration
- Work effectively with other team members within R&D and other departments.
- Plan and execute in-depth analysis of key in-process unit operations using virus qPCR quantitation assay_
- Preparation of protocols, planning documents and execution of experiments in support of qPCR virus quantitation of in-process samples.
- Performing mass balance calculations using virus concentration data to determine process efficiency and to help identify key performance indicators
- Perform data analysis using statistical tools to determine process performance
- Design and implement in-process sampling and monitoring plan for a commercial manufacturing process based on the KPI determination
- Make recommendations for process improvements or further investigation/experiments based on analysis of unit operation performance.
- Communicate the outcome of the experiments effectively and timely to other members of R&D through regular project update summaries and reports.
- Automating qPCR workflow and assay validation_
- Automate various steps in qPCR workflow by leveraging laboratory robotic systems.
- Familiar with validation of molecular assays considered a strong asset
- Execute tech transfer of validated assay to QC department
- Participate in writing Plans, Reports, SOPs, BPRs and other supporting documents required for technology transfer to manufacturing and QC.

**Education**
- Minimum BSc in molecular biology or relevant biological science, with practical experience in qPCR.

**Required qualifications/skills**:

- Demonstrated skills and understanding of nucleic acid extraction/purification from various sources (viral and bacterial culture).
- Experience in developing qPCR workflows, including primer selection/design, interpreting amplification curves, and numerating target concentration.
- Experience in digital droplet PCR is desirable.
- Experience and comfort in working with infectious material (viral and bacterial) in a biological safety level 2 environment.
- Strong work ethic with proven ability to work in a team-oriented environment.
- Excellent communication verbal and written skills. Ability to communicate effectively across different levels within the organization and across different departments.
- Strong organizational and time management skills coupled with the ability to handle multiple priorities and bring projects to completion.
- Experienced in assay validation.

**Job Type**: Fixed term contract
Contract length: 6 months

Flexible Language Requirement:

- French not required

Schedule:

- Monday to Friday

Ability to commute/relocate:

- Mississauga, ON L4Z 1P3: reliably commute or plan to relocate before starting work (required)

**Education**:

- Bachelor's Degree (required)

Work Location: In person

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