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Senior Research Associate I, Protein Engineering
3 months ago
Key Responsibilities:
- Independently plan, perform, and optimize purification workflows of multispecific antibody therapeutics using AKTA (FPLC) systems, gravity flow columns, and high-throughput plate-based methods.
- Perform analytical and biophysical characterization of antibodies and other protein therapeutics for quality control, stability, and developability studies.
- Plan, execute, and evaluate binding studies using SPR, BLI, Kinexa, and/or flow cytometry methods, either independently or in collaboration with teammates.
- Analyze and review data, draw conclusions, and make recommendations for future investigations.
- Initiate and execute novel methods and/or suggest innovative and impactful changes to methods independently or in collaboration with team members.
- Participate in cross-departmental collaborative activities and present data at departmental and project team meetings.
- Seek to understand ongoing projects through attention to scientific literature, industry publications, and internally generated data and employ this understanding to improve contribution to project goals.
- Maintain a clean, organized, and operational lab.
- Conduct all activities in accordance with scientific standards, OH&S regulations, and established policies and practices.
- Actively work to foster an environment of effective and collaborative working relationships across the organization.
- Adhere to Zymeworks’ standard procedures for generating, documenting, and archiving data, maintaining an accurate, up-to-date electronic laboratory notebook.
Education and Experience:
Requires a MSc in a relevant scientific discipline with 3-5 years of relevant work experience, or equivalent combination of education and work experience.
Skills and Abilities:
- Good working knowledge and hands-on experience in several of the following areas: Protein purification (e.g. protein A/G/L, IEX, IMAC, and SEC) and familiarity with AKTA (FPLC) systems.
- Protein analytics: PAGE, CE-SDS, HPLC-SEC, cIEF, HIC, ELISA, DSC, DSF, DLS, MALS.
- Binding affinity measurements by SPR, BLI, or Kinexa.
- Additional experience with flow cytometry, FACS, or other fluorescence cell-based methods would be a plus.
- Experience with developability and stability assessments of antibody-based therapeutics would be desirable.
- Good organizational and time management skills, work effectively in a fast-paced, fast-changing environment.
- Good critical observation with analytical and problem-solving capabilities.
- Good communication skills, including scientific/technical writing and oral skills. Ability to present data effectively at team meetings and inter-departmental meetings.
Total Rewards:
We offer a comprehensive total rewards package, which includes competitive salaries, generous benefits, an outstanding work environment, and excellent opportunities for professional growth. The Canadian base salary range for this full-time position is $73,000 - $XX,000 + bonus + equity + benefits. Please note that the compensation details listed in role postings reflect the base salary only, and do not include bonus, equity, or benefits.
Our team enjoys:
- Industry-leading vacation and paid time off.
- Excellent health and wellness benefits.
- Zymelife health and wellness benefits.
- Paid time off to volunteer in your community.
- Matching country-specific pension savings program.
- Employee Share Purchase Program.
- Employee Equity Program.
All qualified applicants will receive consideration for employment without regard to race, colour, religion, sex, sexual orientation, gender identity, national origin, or disability.
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