Associate Director, Discovery Radiochemistry, Toronto

Found in: beBee jobs CA - 1 week ago

Toronto, Ontario, Canada POINT Biopharma Full time

POINT Biopharma Global Inc. is a globally focused radiopharmaceutical company building a platform for the clinical development and commercialization of radioligands that fight cancer. POINT aims to transform precision oncology by combining a portfolio of targeted radioligand assets, a seasoned management team, an industry-leading pipeline, in-house manufacturing capabilities, and secured supply for medical isotopes including actinium-225 and lutetium-177. POINT's active clinical trials include FRONTIER, a phase 1 trial for PNT2004, a pan-cancer program targeting fibroblast activation protein-α (FAP-α), and SPLASH, the phase 3 trial for PNT2002 for people with metastatic castration resistant prostate cancer (mCRPC) after second-line hormonal treatment.

Location of work

This position will be located onsite downtown Toronto near University Avenue and College Street.

The Associate Director of Discovery Radiochemistry will be a leader and scientific expert in the discovery and development of novel radioligands for use in cancer imaging and therapy. They will work in collaboration with team members, other departments, and external partners (CDMOs) to lead the development of novel radioligands, enable the supply of radiolabeled compounds for preclinical experiments, conduct formulation development, and support the development of radiopharmaceutical manufacturing processes for clinical development.

Responsibilities

  • Demonstrate leadership and management capabilities
  • Oversee the development of the next-generation of radiopharmaceuticals by leading radiochemistry research and development for discovery programs
  • Produce and supply radiolabeled compounds to support the preclinical evaluation of novel radioligands
  • Design and conduct radiolabelling and formulation optimization studies
  • Evaluate and integrate novel technology into the Discovery Radiochemistry team's workflow
  • Support the development of cGMP radiopharmaceutical manufacturing processes to enable clinical development activities
  • Collaborate and communicate effectively with a multidisciplinary team including Preclinical, Translational Radiochemistry, Quality Assurance, and Facilities
  • Interact and maintain strong collaborative relationships with stakeholders including business and industry partners
  • Proactively tracking of innovation and supporting IP filing activities
  • Prepare and deliver presentation for internal and external team meetings
  • Author development reports, manuscripts for publication in journals, and patent applications

Requirements

  • PhD in radiochemistry, organic chemistry, chemical engineering, or a related discipline.
  • Minimum of 7 years of industry experience in the development of novel radiopharmaceuticals
  • Minimum of 3 years of supervisory or management experience in radiochemistry development or radiopharmaceutical manufacturing.
  • Demonstrated project management experience
  • Experienced in radiochemistry development including imaging radioisotopes (ie. F-18, Ga-68, Cu-64, Zr-89, In-111) and therapeutic radioisotopes (ie. Lu-177, Ac-225, Tb-161, Cu-67, Pb-212).
  • Experienced in quality control testing of radiopharmaceuticals including radio-HPLC, radio-ITLC and GC.
  • Functional understanding of the principles of cGMP radiochemistry production requirements
  • Knowledge of environmental health and radioprotection requirements are considered assets.
  • Proven ability to work independently with strong organization and communication skills.
  • Demonstrated ability to successfully prioritize projects and manage timelines in a fast-paced environment.
  • Functional knowledge of GMPs and applicable FDA, EMA, Health Canada, USP, ICH and PDA guidelines.
  • Position will require 0 to 20% of travel within North America and abroad into the EU. A valid passport and eligible to travel into these countries are required.

Benefits

  • Healthcare plan (medical, dental, vision) – effective day 1
  • Disability
  • Life insurance
  • RRSP matching plan
  • Paid Time Off (Vacation, Personal Days, Sick Days & Public Holidays)
  • $500 fitness reimbursement
  • $50 cell phone reimbursement per paycheck ($1,300 per year)

All applicants who are offered employment with POINT Biopharma will be subject to a background investigation. Offers of employment are contingent on the successful completion of a background investigation conducted in accordance with POINT Biopharma policy and state law.

This role works in a hospital setting and it is mandatory for all employees to complete health screens before onboarding. In the event the screen results show non-immunity, vaccines may need to be administered.

POINT Biopharma does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

We do not accept unsolicited inquiries or resumes from agencies.

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