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Analytical Scientist, Radiochemistry

3 months ago

Hamilton, Canada Fusion Pharmaceuticals Full time

Fusion Pharmaceuticals, a member of the AstraZeneca Group, is a clinical-stage oncology company focused on developing next-generation radioconjugates (RCs) as precision medicines. Fusion connects alpha particle emitting isotopes to various targeting molecules to selectively deliver the alpha emitting payloads to tumors. Fusion’s clinical portfolio includes: FPI-2265 targeting prostate specific membrane antigen (PSMA) for metastatic castration resistant prostate cancer currently in a Phase 2 trial; FPI-1434 targeting insulin-like growth factor 1 receptor currently in a Phase 1 trial; FPI-2059, a small molecule targeting neurotensin receptor 1 (NTSR1), currently in a Phase 1 trial; and FPI-2068, a bispecific IgG-based EGFR-cMET targeted radioconjugate currently in a Phase 1 trial. In addition, Fusion is pursuing combination programs between RCs and DNA Damage Response Inhibitors (DDRis) and immune-oncology agents. Fusion has a fully operational Good Manufacturing Practice (GMP) compliant state-of-the-art radiopharmaceutical manufacturing facility to meet supply demand for Fusion's growing pipeline of RCs.


The Analytical Scientist, Radiochemistry role is an onsite lab position in Hamilton, Ontario.


Responsibilities and job tasks may include

  • Lead the analytical method development, physico-chemical property assessments and troubleshooting for a range of radioconjugates (small molecules to mAbs) on the discovery team including HPLC (RP, SEC, HILIC) and LC-MS
  • Execute stability (including plasma) and metabolic assessments of radioconjugates and precursors
  • Identify and develop new analytical techniques and assays to expand or enhance existing programs
  • Translation of analytical methods to manufacturing, external CROs or collaborators
  • Support the team communications in disseminating the results, which may come in the form of writing reports, presenting at workshops and submitting manuscripts and patents
  • Perform qualitative and quantitative analysis, sampling, defining, isolation, concentration, and preservation of samples
  • Setting error limits, validate and verify results through calibration and standardization
  • Maintain clear and current records of work within a laboratory notebook
  • Perform peer/technical review of analytical data
  • Contribute to the organization and maintenance of the radiochemistry laboratories
  • Keep informed of the latest technical developments in nuclear medicine and analytical methods and related fields


Qualifications

  • Driven analytical scientist with a recognized post-secondary education in analytical chemistry
  • PhD, with 0-3 years or M.Sc. with 3-8 years of relevant laboratory experience
  • Excellent troubleshooting skills in the lab, organizational skills and evidence of continued education/upskilling
  • Skilled at analytical method development of radiolabelled compounds including HPLC
  • Strong understanding of medicinal chemistry and good laboratory practices is an asset
  • Experienced with Empower and Mass Lynx software and strong computer skills
  • Proven ability to work independently with strong communication skills and attention to detail, including proficiency in the English language
  • Impressive track record of scientific prowess in the form of publications and/or patents
  • Excel at working in a fast-paced, collaborative environment as a member of a multidisciplinary team
  • Demonstrated ability to successfully prioritize projects and manage timelines
  • Experience with the analysis of an array of targeting vector classes is desirable
  • Experience in the safe handling and analysis of radiometal conjugates is desirable

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.