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Associate Director, Bioanalysis LCMS
30 minutes ago
For 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well‑being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about. Job Summary The Associate Director of Large Molecule Bioanalysis will lead the scientific oversight of our LC‑MS/MS–based large‑molecule bioanalytical service offering. This role requires deep expertise in mass spectrometry for proteins, peptides, antibody‑drug conjugates, and other biologics, including hybrid and immunocapture‑LC‑MS/MS approaches. The successful candidate will be responsible for designing and validating robust bioanalytical assays to support regulated non‑clinical and clinical studies (GLP/GCP). Acting as both a scientific and operational leader. The selected candidate will build laboratory capabilities, oversee study execution, ensure regulatory compliance, and serve as the primary subject matter expert (SME) for internal stakeholders and external partners. In this role, primary responsibilities include: Lead the development, optimization, and validation of LC‑MS/MS methods for large molecule bioanalysis (proteins, peptides, antibody‑drug conjugates, and other biotherapeutics) in biological matrices; Drive the use of advanced workflows, including immunocapture techniques, signature peptide workflows, and hybrid MS strategies; Prepare, review and approve study schedules and draft study plans and amendments for Bioanalytical studies; Prepare and review toxicology study plans and amendments (sections related to the Bioanalytical analysis), in collaboration with the study director; Ensure that the studies are planned efficiently with regard to the experiment required, staff requirements and their qualifications, health and safety legislation, such that the study will satisfy its objectives; Ensure that study personnel are fully aware of their required duties within the studies, including experiment conduct, data collection and integrity; Monitor the laboratory activities during the study by conducting regular visits to the lab, by supervising critical activities and reviewing the records as appropriate; Supervise Bioanalytical laboratory staff in the execution of method development and transfer, validation and sample analysis; Perform appropriate analysis and interpretation of study data generated and advise accordingly; Communicate appropriate information concerning studies to the sponsor, study team, study director, Quality Assurance Program and management so that appropriate decisions and actions are carried out. Key Elements We are looking for the following minimum qualifications for this role: Bachelor’s degree in Chemistry, Biochemistry or related scientific field. Master’s or Doctorate’s degree is a definite asset; Minimum of 10 years of relevant experience including a minimum of 7 years in a scientific position relevant to large molecule bioanalysis by LC-MS/MS; In-depth working experience in the development and optimization of LC-MS/MS methods for the quantification of biomolecules (proteins, peptides, antibody‑drug conjugates) in biological matrices, including hybrid workflows and immunocapture strategies; Excellent organizational and communication skills; Strong problem‑solving and analytical skills; Ability to coach personnel; Experience in a Contract Research environment is an asset. Role Specific Information Location : 445 Boul. Armand-Frappier, Laval, QC, H7V 4B3; Transportation : Free parking. Near the Montmorency Subway. Electric vehicle charging station; Annual bonus based on performance; Schedule : Daytime Monday to Friday; Permanent position as of the hiring, full-time 37.5hrs per week. Why Charles River ? We offer competitive benefits and advantages from day one to support your well‑being; Paid development training; Employee and family assistance program; Excellent welcome program for new employees as well as in‑house advancement and career development opportunities; Access to a doctor and various health professionals (telemedicine); 4 weeks’ Vacation & 10 Personal day policy; Many social activities If you are interested in contributing to the well‑being of our communities, not only across the country but around the world, please join us.This is Your Moment. About Safety Assessment Charles River is committed to helping our partners expedite their preclinical drug development with exceptional safety assessment services, state‑of‑the‑art facilities and expert regulatory guidance. From individual specialty toxicology and IND enabling studies to tailored packages and total laboratory support, our deeply experienced team can design and execute programs that anticipate challenges and avoid roadblocks for a smooth, efficient journey to market. Each year approximately 300 investigational new drug (IND) programs are conducted in our Safety Assessment facilities. About Charles River Charles River is an early‑stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non‑GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market. With over 20,000 employees within 110 facilities in over 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well‑being of many across the globe. We have proudly worked on 80% of the drugs approved by the U.S. Food and Drug Administration (FDA) in the past five years. We’re committed to providing benefits that elevate your quality of life. Based on your position these may include: bonus/incentives based on performance, 401K, paid time off, stock purchase program, Health and wellness coverage, employee and family wellbeing support programs, and work life balance flexibility. Equal Employment Opportunity Charles River Laboratories is an Equal Opportunity Employer - all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status. It is unlawful in some states (including Massachusetts) to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability. If you are interested in applying to Charles River Laboratories and need special assistance or an accommodation due to a disability to complete any forms or to otherwise participate in the resume submission process, please contact a member of our Human Resources team by sending an e‑mail message to This contact is for accommodation requests for individuals with disabilities only and cannot be used to inquire about the status of applications. For more information, please visit #J-18808-Ljbffr
