Associate Principal Scientist, Medicinal Chemistry

At Insmed, every moment and every patient counts — and so does every person who joins in. As a global biopharmaceutical company dedicated to transforming the lives of patients with serious and rare diseases, you'll be part of a community that prioritizes the human experience, celebrates curiosity, and values every person's contributions to meaningful progress. That commitment has earned us recognition as Science magazine's No. 1 Top Employer for four consecutive years, certification as a Great Place to Work in the U.S., and a place on The Sunday Times Best Places to Work list in the UK.

For patients, for each other, and for the future of science, we're in. Are you?

About The Role
Are you a medicinal chemist passionate about the design and strategy behind selecting the right compounds to make? Are you used to using computational tools to analyse data and drive value across DMTA cycle? Insmed Cambridge are looking for an Associate Principal Scientist, this role plays a pivotal part in supporting the speed of decision making vital to design and synthesize novel molecules that translate our groundbreaking biological discoveries into pioneering medicines.

What You'll Do

• Assume a vital role as a medicinal chemist lead on a discovery project.
• Play a lead role supporting projects from concept to clinic, ensuring alignment with overall program goals and timelines.
• Utilise computational tools such as spotfire to conduct data analysis and synthetic techniques to drive drug design, positively impacting progression of medicinal chemistry programs.
• Apply efficient and creative methodologies to complete hit-to-candidate medicinal chemistry campaigns to the highest standards and in short timescales.
• Manage or mentor a team of skilled chemists, fostering a collaborative and innovative environment.
• Contribute to the execution of a broad range of laboratory skills covering a range of different chemistries to successfully access synthetic targets on milligram to gram scale.
• Troubleshoot and resolve synthetic and analytical challenges.
• Collaborate across-functions (biology, pharmacology, ADME) to drive efficiencies in the Design-Make-Test-Analyse cycles
• Maintain competitive awareness around advances in synthetic and/or medicinal chemistry and identify opportunities to publish chemistry-related progress, lead compilation and filing of patent applications.

Who You Are

• A MSc or PhD qualification and a proven track record in industry (7+ yrs) with experience in a leadership or mentoring role.
• Proven expertise in ideas/hypothesis generation based on structure-based drug design and data analysis (SAR) to address typical medicinal chemistry challenges including ADME and physicochemical properties.
• A passion for new technologies and competence in the use of Spotfire and other data visualisation and machine learning models.
• Theoretical and practical synthesis knowledge with strong problem-solving skills.
• Exceptional communication skills coupled with a strong focus on leading change and collaboration.
• This role will require you to work flexibly from our brand-new offices and labs situated in Babraham Research Campus, South Cambridge.

Life at Insmed
Our research site in Cambridge, UK is situated in brand new labs and offices at the Babraham Research Campus—a leading hub for bioscience innovation and collaboration. Our team of biologists, human geneticists, bioinformaticians, data scientists, computational and synthetic chemists bring together a wide range of technologies and modalities to deliver powerful new ways of treating serious diseases.

At Insmed, you'll find a culture as human as our mission—intentionally designed for the people behind it. You deserve a workplace that reflects the same care you bring to your work each day, with support for how you work, how you grow, and how you show up for patients, your team, and yourself.

Our Offerings Include

• Flexible work schedules with purposeful in-person collaboration
• Competitive retirement benefits, global equity awards, and participation in our Employee Stock Purchase Plan (ESPP)
• Career development through the Insmed Learning Institute, external programs, LinkedIn Learning, and role-specific training
• AI-powered and on-demand learning tools, including a digital assistant to help navigate internal resources
• Hybrid-friendly technology and IT support for seamless teamwork across locations and time zones
• Global recognition programs and Employee Resource Groups
• Eligibility for specific programs may vary and is subject to the terms and conditions of each plan

Eligibility for specific programs may vary and is subject to the terms and conditions of each plan.

*Insmed Incorporated is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected Veteran status, age, or any other characteristic protected by law.

Unsolicited resumes from agencies should not be forwarded to Insmed. Insmed will not be responsible for any fees arising from the use of resumes through this source. Insmed will only pay a fee to agencies if a formal agreement between Insmed and the agency has been established. The Human Resources department is responsible for all recruitment activities; please contact us directly to be considered for a formal agreement.

Insmed is committed to providing access, equal opportunity, and reasonable accommodation for individuals with disabilities in employment, its services, programs, and activities. To request reasonable accommodation to participate in the job application or interview process, please contact us by email at

and let us know the nature of your request and your contact information. Requests for accommodation will be considered on a case-by-case basis. Please note that only inquiries concerning a request for reasonable accommodation will be responded to from this email address.

Applications are accepted for 5 calendar days from the date posted or until the position is filled.*