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Principal Scientist
2 weeks ago
AbCellera is breaking the barriers of conventional drug development to propel antibody-based medicines from target to clinic. We are a team of scientists, engineers, creatives, and business professionals who believe that advancing science enhances lives. We have developed technologies to unlock high-value drug targets, including antibody-drug conjugates and T-cell engagers for cancer, and complex transmembrane proteins for indications such as metabolic and endocrine conditions, pain, and autoimmunity.
We are seeking an experienced and exceptional individual for the role of Principal Scientist - Pharmacokinetics, someone who has a passion for understanding how models can predict therapeutic responses to human disease. This scientist will help to build out our pharm-tox capabilities so we can move programs faster and with less risk to the clinic. This scientist will be responsible for pharmacokinetic/pharmacodynamic (PK/PD) modeling and human dose projections, supporting both discovery and development teams.
**How you might spend your days**:
- Designing and executing PK data packages tailored for individual programs
- Predicting and verifying appropriate dosing regimens to demonstrate antibody PK/PD relationships across a range of drug targets and disease areas
- Overseeing pharmacokinetics studies to support antibody design and assessment
- Collaborating with teams across the company to generate data and interpret them
- Training and mentoring more junior scientists
- Evaluating new technology and testing new models to better predict human illness
- Reporting findings to our teams and partners to support data-driven decision making
**We’d love to hear from you if you**:
- Have a proven track record of building PK datasets to support successful drug development programs, from early discovery and into later stages
- Are an expert in designing PK studies and conducting PK/PD data analysis, using WinNonlin or other similar software
- Enjoy the teamwork that comes with working on complicated biological questions and building data sets that help to predict the success of therapies
- Are genuinely curious, with an interest in discussing innovative ideas in a highly collaborative and fast paced environment
- Have excellent documentation and organizational skills, as well as strong verbal and written communication skills
- Have experience authoring sections of regulatory submissions and are well-versed in scientific and regulatory standards for bioanalysis of biologics (desirable)
**What we offer**:
AbCellera’s hiring range for this role is CAD $141,600 - $177,000 annually, commensurate with your education and job-related knowledge, skills, and experience. In addition to base salary, we offer equity, annual bonus dependent on team and company performance, and a 6% (non-match) RRSP contribution.
You will have a CAD $1,500 annual Active Lifestyle Allowance, annual vacation, opportunity for flexible work arrangements, professional development opportunities, and comprehensive health benefits. Scientific and technical mentorship is a priority. And you’ll find we prioritize team building and connections across AbCellera.
**About AbCellera**:
AbCellera is a global company that discovers and develops antibody-based medicines that help people live longer, happier, and more productive lives. We are focused on bringing innovative medicines to patients, both by advancing our internal pipeline of programs and partnering with companies that have novel science or innovative technology.
And it all starts with our team. We’ve built a place where people feel they are part of something bigger than themselves. A place that exists to push the limits of science and technology, and aims to bring better therapies to patients.
We look for people with drive and energy. Idealists. People we love and people we trust. This may be unconventional, but it is the key to our success.
**To apply**:
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