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Research Assistant, in Vivo Pharmacology

2 weeks ago

Montréal, Canada Ventus Therapeutics Full time

Research Assistant, In vivo Pharmacology

**About us**:
Ventus Therapeutics is a biopharmaceutical company deploying leading-edge structural biology and computational chemistry tools to create novel small molecule medicines for challenging targets, with an initial focus on immunology, inflammation and neurology.

Our proprietary drug discovery platform, ReSOLVE, gives us the ability to discover and develop medicines through unique insights into protein targets and to create dynamic blueprints that can guide the development of differentiated small molecule medicines. Our lead programs target key innate immune modulators, including NLRP3 and cGAS. We aim to use the ReSOLVE platform to improve the way medicines are discovered and developed, with the ultimate goal of restoring the health of people facing serious illnesses.

**Position Overview**:
**Key Duties and Responsibilities**:

- Perform all _in vivo_ DMPK studies (PKs) in rodents (mouse and rat) in a regulated environment, following standard operating procedures (SOPs)
- Real-time documentation of experimental work
- Provide support in the lab on pharmacology studies led by the team, including pharmacodynamic and efficacy studies in mouse

**Requirements**:

- Animal Health diploma or relevant experience with laboratory mice or rats
- 1+ year of experience in small animal handling and basic _in vivo _procedures in rodents, such as drug administration, blood and tissue collection, and animal care
- Ability to work independently and to adapt to project needs
- Attention to detail, excellent organization, communication, and interpersonal skills
- Experience with both mouse and rat handling is preferred
- Functional written and oral bilingualism (French and English) is preferred
- ______________________________________________

Assistant de recherche, Pharmacologie in vivo

**À propos de nous**:
Ventus Thérapeutique est une société biopharmaceutique qui déploie des outils de pointe en biologie structurelle et en chimie computationnelle pour créer de nouveaux médicaments à base de petites molécules pour des cibles difficiles, avec un accent initial sur l'immunologie, les maladies inflammatoires et la neurologie.

Notre plateforme exclusive de découverte de médicaments ReSOLVE nous donne la possibilité de découvrir et de développer des médicaments grâce à une connaissance unique des cibles protéiques et de créer des plans dynamiques qui peuvent guider le développement de petites molécules différenciées. Nos principaux programmes ciblent des modulateurs clés de l'immunité innée, notamment NLRP3 et cGAS. Nous souhaitons utiliser la plateforme ReSOLVE pour améliorer la manière dont les médicaments sont découverts et développés, dans le but ultime de rétablir la santé des personnes atteintes de maladies graves.

**Aperçu du poste**:
**Principales tâches et responsabilités**:

- Réaliser toutes les études DMPK (pharmacocinétique) _in vivo _chez les rongeurs (souris et rat) dans un environnement réglementé, en suivant les procédures opératoires normalisées (PON).
- Documentation en temps réel du travail expérimental
- Fournir un soutien au laboratoire pour les études pharmacologiques menées par l'équipe, y compris les études pharmacodynamiques et d'efficacité chez la souris.

**Exigences**:

- Diplôme en santé animale ou expérience pertinente avec des souris ou des rats de laboratoire
- 1+ année d'expérience dans la manipulation de petits animaux et les procédures de base _in vivo _chez les rongeurs, telles que l'administration de médicaments, le prélèvement de sang et de tissus, et les soins aux animaux.
- Capacité à travailler de manière indépendante et à s'adapter aux besoins des projets.
- Souci du détail, excellentes capacités d'organisation, de communication et de relations interpersonnelles.
- Une expérience de la manipulation de souris et de rats est préférable
- Un bilinguisme fonctionnel écrit et oral (français et anglais) est préférable.

**Job Types**: Full-time, Permanent

**Benefits**:

- Casual dress
- Company events
- Extended health care
- On-site parking
- Paid time off
- Stock options

Schedule:

- Monday to Friday

Supplemental pay types:

- Bonus pay

Ability to commute/relocate:

- Montréal, QC H4S 2A1: reliably commute or plan to relocate before starting work (required)