Postdoctoral Fellow

3 days ago

Vancouver, Canada UBC Full time

Academic
Job Category
Faculty Non Bargaining
Job Title
Postdoctoral fellow
Department
Lynn Research Lab General Surgery | Department of Surgery | Faculty of Medicine (Francis Lynn)
Posting End Date
April 3, 2025
**Note**: Applications will be accepted until 11:59 PM on the Posting End Date.
Job End Date
Jun 30, 2026
This offer is conditional upon successful completion of a Criminal Record Check.
Postdoctoral Fellowship in Cell Therapy for Diabetes at UBC
**Project**: In persons with T1D, the insulin-producing beta cells of the pancreas are destroyed by one's own immune system. Insulin remains the best treatment, but even with close glucose monitoring and insulin administration, persons with diabetes still face complications. A cure for diabetes may lie in the replacement of insulin-producing cells by transplantation. Hundreds of patients worldwide have received transplants of islets enabling better blood glucose control without the need for insulin administration. Yet because there are not enough organ donors, new sources of insulin-producing cells are needed for the millions living with this disease. Moreover, most islet transplants fail within a few years, requiring patients to return to insulin injections. Two recent advances may transform cell therapy in diabetes. First, human insulin-producing cells can now be generated from stem cells in a laboratory dish within a few weeks. Second, the genes of cells can be engineered to produce proteins that may enhance their survival and function.
The PDF will edit the genome of human embryonic stem cells in order to make insulin-producing cells that will function better and survive longer upon transplantation into persons with type 1 diabetes. This will involve adding genes that will protect beta cells from stress, inflammation and adaptive immunity. These modified cells will first be tested by transplantation into models of human diabetes. We are well-poised to move these cells into clinical trial, as our team includes leaders in cell manufacturing and clinical cell therapy. The goal is to produce a new and improved cell source for cell replacement therapy in T1D.
The expected pay for this position is $70,000 per year + benefits.
**Application Process**: Interested applicants should submit a CV and cover letter that details their experience and contact details for 3 references.

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