Analytical Scientist

Great Minds. One Goal. Canada's Success.

Help bring research to life and drive your career forward with the National Research Council of Canada (NRC), Canada's largest research and technology organization.

We are looking for a Technical Officer to support our Human Health Therapeutics research centre. The Technical Officer would be someone who shares our core values of Integrity, Excellence, Respect and Creativity.

This day may also include training in one or several different techniques - as well as helping to train other colleagues, assisting in administrative and support roles such as purchasing of reagents/supplies, preparing scientific reports, assisting in the development of new analytical assays, attending internal and external meetings, writing standard operating procedures (SOPs), documenting experiments in laboratory notebooks, general maintenance of equipment and laboratory facilities, and presenting data at internal meetings.

You will interact with, and have the opportunity to learn from, a diverse array of teams within the NRC community that have different expertise as well as many Canadian industrial (Biotech/Pharma) and academic partners.

**Your Challenge (continued)**:
In any given week, you will have the opportunity to work on important drug development projects with potentially national significance - examples are provided in the links below.
- Made-in-Canada cancer therapy offers patients new hope
- Unlocking the potential of biologics to put a bulls-eye on cancer - National Research Council Canada
- Supporting innovation through collaboration: Forbius on the move - National Research Council Canada

This Analytical Scientist position would appeal to someone who is interested in the biology of disease and eager to learn how biologics-based therapeutic drugs are characterized and developed to treat human diseases such as cancer, viral infections and rare genetic diseases.

Someone who is flexible and has a passion for working hands-on in a laboratory setting, learning new techniques, helping to find solutions to challenging scientific problems and interacting with other scientists with diverse backgrounds.

If you are that person, then this is the perfect role for you

**Screening Criteria**:
**Education**:
Bachelor degree in Analytical Chemistry, Biochemistry, Biotechnology, Virology, Molecular Biology, Immunology or relevant related discipline.

Other relevant education in Life Science combined with significant industrial experience may be also considered.

For information on certificates and diplomas issued abroad, please see Degree equivalency

**Experience**:

- Experience in supporting the development of analytical assays.
- Experience in mammalian cell culture for use in cell-based assays.
- Experience working with and characterizing viral vectors and other biologics-based therapeutics such as antibodies, enzymes, recombinant proteins, VLPs, liposomes, exosomes, vaccines.
- Experience in ELISAs and one or more of the following functional assays; surface plasmon resonance (SPR), biolayer interferometry(BLI), enzyme kinetics, flow cytometry, plate-based methods such as AlphaLisa, FRET, proximity ligation assay (PLA), fluorescence polarization (FP), time-resolved fluorescence (TRF).
- Some experience in one or more biophysical techniques such as analytical chromatography, analytical ultracentrifugation (AUC), capillary isoelectric focussing (cIEF), differential scanning calorimetry/fluorimetry (DSC/DSF), fluorescence-based spectroscopy, circular dichroism (CD), CE-SDS, western blots, PCR/qPCR/ddPCR/dPCR and dynamic light scattering (DLS), Western Blot
- Some experience molecular biology techniques or the use of design of experiments (DOE).

**Condition of Employment**:
Reliability Status

**Language Requirements**:
English or French

Information on language requirements and self-assessment tests

**Assessment Criteria**:
**Technical Competencies**:

- General knowledge of basic protein structure and biochemistry.
- Working knowledge of the proper preparation, physical manipulation and storage of biological samples. Examples include the preparation of buffers, serial dilutions, pH measurement and adjustment, aliquoting samples, centrifugation of samples, dialysis/buffer exchange, concentrating samples, and sterile techniques.
- Working knowledge and understanding of basic biochemical, biophysical and functional assays for proteins.
- Ability to contribute to the design, development and optimization of analytical assays by performing basic searches for relevant information in technical manuals, online databases, and journal articles.
- Ability to clearly and accurately document results and analysis from experiments and clearly communicate results at regular team/project meetings.
- Ability to maximize efficient use of time by multitasking both inside and outside the laboratory.
- Working knowledge of standard software such as Microsoft Word, Excel, PowerPoint and GraphPad.

**Behavi