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Senior Medicinal Chemist
2 months ago
Neuly is a biotechnology company dedicated to the discovery and development of novel pharmaceuticals based on known psychedelic compounds. Our mission is to create precision medicines for brain and mental health.
The OpportunityWe are seeking a highly skilled synthetic/medicinal chemist to join our team and contribute to the advancement of our psychedelic compound library. The ideal candidate will have expertise in novel drug discovery and be able to design and perform diverse organic compound and library syntheses, purifications, and analysis.
Key Responsibilities- Contribute to library synthesis, lead identification, and optimization programs, including structure-based and ligand-based drug design.
- Apply medicinal chemistry principles and SAR principles to identify and optimize lead molecules.
- Utilize modern synthetic strategies and computational techniques to design and execute the synthesis of target molecules and libraries.
- Analyze reaction products to determine synthesized compounds.
- Conduct purification of synthesized compounds using modern chromatographic techniques.
- Collaborate with a multidisciplinary team in the R&D of novel psychedelic medicines.
- Research current literature to evaluate and implement new reactions, techniques, and technologies to advance projects.
- Maintain accurate records of observations, measurements, techniques, procedures, and conclusions.
- BS, MS, or PhD in organic chemistry, medicinal chemistry, or related disciplines.
- Minimum 10+ years' experience in drug discovery.
- Strong knowledge of organic chemical reactions, mechanisms, and the ability to plan and develop complex multi-step syntheses.
- Knowledge of computational chemistry is ideal.
- High proficiency with thin layer chromatography, column chromatography, recrystallization, and other purification methods.
- Fundamental understanding of ADME properties and how to address issues such as metabolic stability.
- Strong interpersonal and communication skills.
- Strong critical thinking, analytical, trouble shooting, and problem-solving skills, with the ability to exercise independent judgment.
- Able to work collaboratively in cross-functional multidisciplinary teams.
- Strong organization, prioritization, and time management skills, with high attention to detail.
- Motivated and self-directed with a demonstrated ability to work with minimum supervision in a fast-paced, dynamic environment.
