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Senior Manager of Pilot Plant Operations
3 months ago
About AbCellera
AbCellera is at the forefront of revolutionizing drug development, specializing in the advancement of antibody-based therapies. Our diverse team comprises scientists, engineers, creative thinkers, and business experts dedicated to enhancing lives through scientific innovation. We have pioneered technologies that unlock valuable drug targets, including antibody-drug conjugates and T-cell engagers for cancer treatment, as well as complex transmembrane proteins aimed at addressing metabolic and endocrine disorders, pain management, and autoimmune diseases.
Position Overview
We are looking for a Senior Manager of Pilot Plant Operations to spearhead the technical and strategic direction of our 200L scale pilot manufacturing facility. This role is crucial for generating high-quality materials for CMC development, ensuring that the products meet regulatory standards for GLP toxicology studies.
Key Responsibilities
- Deliver strategic, technical, and tactical leadership within the manufacturing, science, and technology teams while overseeing the operations of a 200L scale pilot manufacturing facility.
- Provide expert guidance in process optimization, scale-up, technology transfer, and troubleshooting.
- Lead scientific initiatives and project management for various early-stage development projects.
- Promote and uphold high safety standards within the pilot plant environment.
- Conduct detailed planning, coordination, implementation, tracking, and communication to ensure timely material delivery while adhering to production schedules.
- Assume responsibility for the successful execution of manufacturing campaigns, focusing on product yield, quality, consistency, and adherence to project timelines.
- Evaluate and test new technologies and equipment with a science-based approach to reduce costs and streamline manufacturing processes.
- Implement and manage a comprehensive equipment maintenance and management system, collaborating with site-based support functions such as Facility Engineering and Metrology teams.
- Oversee the supply chain requirements of the Pilot Plant, ensuring critical supplies are available and coordinating new equipment or supplies for technology transfers.
Qualifications
- A minimum of 8-12 years of industrial experience in process development, manufacturing, or MSAT, with at least 4 years in a leadership capacity, preferably in antibody-related fields.
- A bachelor's or master's degree in biotechnology, chemical/biochemical engineering, or a related life-science discipline.
- Experience in scale-up processes, technology transfer, batch documentation, and data management.
- Proven leadership experience in managing teams and developing personnel to operate pilot-scale manufacturing equipment.
- Strong analytical skills in pilot-scale process and product data, with practical experience in establishing processes for advancing investigational medicinal products.
- Familiarity with regulatory requirements related to CMC activities for biologics, with experience in authoring regulatory submissions being a plus.
- A passion for team development and a track record of establishing manufacturing capabilities.
- Adept at thriving in fast-paced environments with evolving priorities, employing pragmatic, risk-based decision-making in process development and manufacturing.
Compensation and Benefits
The compensation range for this position is CAD $139,000 - $173,800 annually, commensurate with education and relevant experience. In addition to the base salary, we offer equity options, an annual performance-based bonus, and a 6% RRSP contribution. Employees will also receive a CAD $1,500 annual Active Lifestyle Allowance, vacation time, flexible work arrangements, professional development opportunities, and comprehensive health benefits. Mentorship in scientific and technical areas is a priority, fostering community and connections across AbCellera.
AbCellera is committed to discovering and developing innovative antibody-based medicines that improve the quality of life for patients. Our mission is to advance science and technology to deliver better therapies to those in need.
