PRIME-RNA Platform Manager

We are looking for a manager to lead the development and operations of the Preclinical In Vivo Modeling & Evaluation of RNA Therapeutics Platform (PRIME-RNA), a new translational platform of the Sidney-Altman Hub at the Montreal Clinical Research Institute (IRCM).

You will play a central role in the day‑to‑day management of operations and the execution of activities, ensuring a harmonious workflow and fostering collaboration between multidisciplinary teams. This position offers a unique opportunity to contribute to cutting‑edge research on RNA therapies and to stimulate innovation in RNA biology.

Tasks and responsibilities

- Project management and execution:

- Own the end‑to‑end user workflow: intake, scoping, scheduling, execution, reporting.

- Develop, optimize experimental procedures and carry out laboratory work in collaboration with the technical team to support the following services:

- In vivo feasibility studies for ASO/siRNA/mRNA‑LNP (dose‑range, تف; schedule, route)

- Target engagement assays (qPCR/ddPCR, splice modulation, western blot, RNA‑seq)

- PD biomarkers and on/off‑target analyses

- Efficacy testing with electrophysiological, behavioural, and imaging endpoints

- Safety and toxicology assessment (clinical chemistry, hematology, histopathology)

- Quantitative PK/PD modeling

- Longitudinal in vivo imaging

- Develop and maintain a complete project plan, including timelines, deliverables, and resource allocation.

- Compile results and produce reports to deliver to clients.

- Contribute to the development of the business model and service offering of the IRCM’s Sidney‑Altman Hub in therapeutic RNA.

- Operational and Budget Management:

- Oversee the day‑to‑day operations of the PRIME‑RNA platform and its installation, ensuring optimal performance and efficiency.

- Collaborate with scientists, researchers, technicians, and industry partners to coordinate workflow, resolve issues, and implement improvements.

- Manage internal and external client relationships.

- Manage and optimize the allocation of resources, including personnel, equipment and materials, to ensure projects are executed on schedule and within budget.

- Collaborate with finance management to track expenses and optimize profitability.

- Collaboration and Communication:

- Foster a collaborative and communicative environment among team members, researchers and external collaborators.

- Regularly communicate project updates, challenges and achievements to stakeholders.

- Quality Assurance and Regulatory Compliance:

- Maintain and evolve SOPectomy for dosing routes (IT, ICV, parenchymal/CED, SC, IV, IO), tissue processing, analytics, imaging, and PK/PD modeling.

- Stay up to date with relevant techniques, regulations and industry standards related to RNA‑based therapeutic approaches.

- Ensure that the PRIME‑RNA platform complies with all applicable guidelines and regulations.

Job Requirements

- Ph.D. in Molecular Biology, Biochemistry, Neuroscience, Pharmacology, Immunology, or a related field, with demonstrated hands‑on experience in laboratory research and/or in vivo drug discovery.

- Demonstrate solid expertise in mouse experimentation (colony monitoring, cohort planning, injections, tissues harvest, drug treatments, in vivo imaging) and molecular assays.

- Experience in IND‑enabling project management in an industrial or academic research context is a very strong asset.

- Experience with IACC/CCAC animal ethics, strong documentation discipline and SOP authorship are preferred. Previous experience as a Study Director in a GLP/non‑GLP work environment will be an asset.

- Expertise with small animal imaging (bioluminescence, fluorescence, etc.) and/or with drug pharmacodynamics and toxicity profiling in mice is an asset.

- Demonstrate strong organizational and leadership skills, with teamwork ability and to prioritize effectively.

- Master advanced communication and interpersonal skills to foster collaboration between diverse teams.

EMPLOYEE BENEFITS

- Life and health insurance plans.

- RREGOP pension plan: benefit from an advantageous retirement plan to help secure and plan your future.

- 12 paid statutory holidays and 10 paid sick or personal days per year.

- 20 vacation days after one year of service within the reference period.

- Employee Assistance Program (EAP) and telemedicine services.

- 35‑hour workweek with a 3‑year contract.

How to Apply

Please submit your résumé and cover letter to the following address: RecruteRH@ircm.qc.ca , indicating the position “Prime‑RNA Platform Manager” in the subject line of your email.
Only candidates selected for an interview will be contacted.

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