Research Associate
1 week ago
Please refer to the
job aid for instructions on how to apply.
Position Summary:
Does in vitro and in vivo signalling bias translate into differences between the behavioral effects of distinctly biased agonists? This question will be explored in the context of the 5-HT2A receptor.
We will initially test a general category of psychedelics with LSD, DMT, 5-MeO-DMT, and psilocin (for the pro-drug psilocybin), each acting as an agonist at the 5-HT2A receptor. Structurally, all of these possess tryptamine backbones. Despite this commonality, it remains to be seen whether they all activate 5-HT2A receptors in the same manner, that is, whether they all activate the same G protein or b-arrestin partners. Exceptions to this description includes two highly selective 5-HT2A phenethylamines: DOI, an agonist acting as a psychedelic and MDL100907, an antagonist, which as such might serve as a useful research tool, and lisuride which is structurally related to LSD and generates 5-HT2A receptor activation but lacks the associated behavioral effects suggesting key differences with respect to engagement of second messenger systems. Duties include:
- Profiling of multiple compounds in HEK 293 cells and primary neurons- Generating SOPs to monitor signaling and functional selectivity of target GPCRs- in primary neurons- Generating signaling signatures at single cell resolution for selected GPCRs in- different physiological settings.- Profiling and behavioural correlates in rat models- Training undergraduate and graduate students.- Preparing publications that emerge from this work.
Education/Experience:
- PhD with five years of postdoctoral experience. Direct experience in the GPCR field, both in vitro and in vivo use of biosensors. Experience with viral versions of FRET-based biosensors of PKA and ERK to assess signalling profiles of active and interesting compounds in primary neurons.- Experience with a broad panel of FRET-based biosensors would be used in HEK 293 primary neurons to examine differential G protein coupling, β-arrestin recruitment and downstream protein kinase activation (PKC reflecting Gq activation, PKA- reflecting Gs and Gi activation, Src
- reflecting b-arrestin.- Experience with high content imaging systems.
Other Qualifying Skills & Abilities:
- Ability to teach and interact with trainees.- Knowledge of French and English: McGill University is an English-language university where day to day duties may require English communication both verbally and in writing. The level of English required for this position has been assessed at a level #4 (qualifier) on a scale of 0-4.- Planned Start Date & End Date of appointment: April 15, 2024 - July 14, 2024- Work schedule is Monday to Friday (On-site) 35h/week.
The position is covered by the Association of McGill University Research Employees (AMURE) collective agreement.
Hourly Salary:
$32.79
- Hours per Week:
- 35 (Full time)
- Location:
- McIntyre Medical
- Supervisor:
- Professor
- Position Start Date:
- 2024-04-02
- Position End Date:
- 2024-07-14
- Deadline to Apply:
- 2024-04-09
This position is covered by the Association of McGill University Research Employees (AMURE) collective agreement.
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