Research Associate

3 weeks ago

Toronto, Canada SickKids Full time

**About SickKids**:
Dedicated exclusively to children and their families, The Hospital for Sick Children (SickKids) is one of the largest and most respected paediatric healthcare centres in the world. As innovators in child health, we lead and partner to improve the health of children through the integration of healthcare, leading-edge research and education. Our reputation would not have been built - nor could it be maintained - without the skills, knowledge and experience of the extraordinary people who come to work here every day. SickKids is committed to ongoing learning and development, and features a caring and supportive work environment that combines exceptionally high standards of practice.

When you join SickKids, you become part of our community. We share a commitment and determination to fulfill our vision of _Healthier Children. A Better World_.

Don’t miss out on the opportunity to work alongside the world’s best in paediatric healthcare.

**Position Description**:
We are seeking a highly motivated new member to join our team, manage the lab and assist with experiments (**Research Associate**). The successful incumbent will join a high functioning and collaborative lab with research focused on kidney development and disease modeling using transgenic mouse models and kidney organoids. This job requires a highly organized individual with outstanding time management, excellent communication, and advanced technical skills able to support trainees and the PI. They will assist in research, training, and manage various aspects of the lab.

Our Research Associate will play an integral supervisory role in providing continuity of research and managing the lab to ensure efficient and effective productivity, encouraging research excellence and integrity.

**Here's What You'll Get To Do**
- Support various research projects within the group. Projects focus on the investigation of signaling pathways involved in renal development, and will involve mouse genetics, CRISP/Cas9-mediated gene targeting, next-generation sequencing (i.e. RNA Sequencing, single-cell RNA sequencing) using mouse tissue and/or iPS-generated organoids.
- Take leadership on an independent research project in the lab and provide general oversight on all other research projects. Assist the PI with reporting, manuscript preparation, reviews, etc.
- Take ownership on laboratory safety including training, updating biorisk permits, performing laboratory inspections and participating on program wide safety committees.
- Manages all aspects of the laboratory animal colony, including animal husbandry, updating animal use protocols, breeding strategies, animal transfers, purchases, training, genotyping, and coordinating with mouse facility staff.
- Training others in the lab on animal husbandry/colony maintenance (i.e. weaning, ear notching, genotyping, etc.)
- Responsible for preparation and update of regulatory protocols, including REB submissions and animal use protocols.
- Responsible for the organization of the laboratory and ordering supplies (inventory management). General lab support through identification of needed supplies, stocking/aliquoting/storing of supplies.
- Maintaining equipment (e.g., PCR machines, pH meters, scales, microscopes, BSC, incubators, fume hoods, computers, pipettes, water baths, etc.)
- Proficient (teaching level knowledge) in basic molecular biology laboratory techniques including nucleic acid handling (purification, amplification), immunohistochemistry, microscopy, protein handling, western blotting.
- Performs advanced, highly technical work of a professional nature, and provides leadership within the research group on technical matters; supervises and takes responsibility for some aspects of the laboratory research. Provides a continuity of research.

**Job Knowledge**
- Conducts research **under the direction **of a Faculty Member within the Research Institute.
- Carries out a research project within the group; and/or uses specialized expertise or knowledge in a particular field to contribute to a team project.
- Performs advanced, highly proficient scientific work such as planning and conducting a series of experiments, correlating data obtained, evaluating results, preparing and presenting reports and findings and preparing peer reviewed scientific manuscripts.
- Provides direction within the research group on technical matters and remains current on research of current principals and theories. Mentor students and other lab staff.

**Decision Making**
- The Research Associate works in collaboration with the PI to determine what design and analytic methods are appropriate for a given research study. Where a particular approach cannot be used because of the complexity of the research design or question, the Research Associate will research alternate methods or develop a new approach. The Research Associate will then lead the implementation of the study.

**Self Management**
- Works under the direction of P

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