Biostatistician, Translational Medicine

3 months ago

Toronto, Canada SickKids Full time

**About SickKids**:
Dedicated exclusively to children and their families, The Hospital for Sick Children (SickKids) is one of the largest and most respected paediatric healthcare centres in the world. As innovators in child health, we lead and partner to improve the health of children through the integration of healthcare, leading-edge research and education. Our reputation would not have been built - nor could it be maintained - without the skills, knowledge and experience of the extraordinary people who come to work here every day. SickKids is committed to ongoing learning and development, and features a caring and supportive work environment that combines exceptionally high standards of practice.

When you join SickKids, you become part of our community. We share a commitment and determination to fulfill our vision of _Healthier Children. A Better World_.

Don’t miss out on the opportunity to work alongside the world’s best in paediatric healthcare.

**Position Description**:
**Biostatistician**

The Subbarao lab studies how early-life exposures and experiences shape lifelong health. Our current research is focused disentangling the heterogeneity of asthma by using sophisticated statistical approaches that longitudinally characterize asthma phenotypes and endotypes in the CHILD cohort study and other clinical asthma datasets.

Our team is transdisciplinary, combining expertise in physiology, statistics, epidemiology, nutrition and maternal-child health. We collaborate and use clinical cohorts and administrative databases. We also work closely with health care professionals and patients. We have a diverse group of trainees from undergraduate students, clinical trainees and graduate students to post-doctoral fellows.-
**Current projects cover a broad range of topics such as**:

- Early life determinants (e.g. respiratory infection, dust allergens, and phthalates) of childhood atopy, obesity, and asthma endotypes
- Implementation of clinical studies for early asthma screening and evaluation of targeted asthma interventions
- Trials in preschool asthma of therapeutics to establish biomarkers of response to therapy and to differentiate endotypes of asthma that may be predictive of prognosis.
- Gene-environment interaction and asthma development
- Clinical predictors (e.g. blood eosinophil, nasal microbiome) of asthma and atopic diseases in later life
- Translation of epidemiologic findings in CHILD study to clinical asthma cohorts

**Required Biostatistician skills**
- Proficiency in R and SAS languages.
- Ability to work in a multidisciplinary team; this includes capacity to teach statistical concepts and assist lab members with R/SAS coding/conceptual questions
- Ability to interpret statistical output for and with clinicians and trainees
- Ability to incorporate feedback and adjust methodological approaches in a timely manner
- Experience with Microsoft office package (Word, PPT, Excel) is required
- Ability to clearly and effectively present results to an audience and/or team in a regular basis through written and oral communication channels.
- Knowledge of basic epidemiological concepts is an asset.
- Experience with advanced visualization creation and editing tools such as Adobe Illustrator, Biorender, ggplot and Inkscape is an asset.
- Experience in research related to pediatrics, asthma, allergy and/or pulmonary function is an asset.
- Demonstrated commitment to advancing and aiding in the pursuit of equity, diversity and inclusion objectives.

**Biostatistician responsibilities**
- Work with the principal investigator and/or research associate to develop detailed statistical analysis plans based on a given research question
- Provide trainees with input, coding and interpretation of complex statistical methods. This will require the ability to work on multiple projects simultaneously, some in the capacity of consultancy, and others with an active role in data analysis
- Cleaning, manipulation, and detailed data exploration and diagnostics through visualization and tabulation of several variables at once.
- Perform high-quality statistical analysis, including but not limited to generalized regression models, mixed effect models and other approaches for repeated measures data (e.g. GEE), longitudinal trajectory analysis (e.g. GBTM, LCA), and mediation analysis.
- Generate deliverables for research publication and grants.
- Actively ensure data integrity and quality through detailed review of trainees coding and analysis prior to publication.

**Relationships**
- Reports to Principal Investigator and research associate
- Works closely and in collaboration with Biostatisticians in the team

**Software**
- Proficiency in R is required
- Proficiency in Microsoft word package is required (Word, PPT, Excel)
- Experience in SAS, MPlus, Stata is an asset
- Experience in Abode Illustrator, Inkscape, Biorender is an asset

**Employment Type**:1.0 FTE Temporary 1 Year Contract with Modified Benefits-
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