Barriers to The Transmission of

2 months ago

Sherbrooke, Canada Université de Sherbrooke Full time

**Barriers to the transmission of multidrug-resistance conjugative plasmids of the IncC group**:

- Réf
- **ABG-111116**
- Sujet de Thèse- 13/02/2023- Autre financement public- Université de Sherbrooke- Lieu de travail- Sherbrooke - Canada- Intitulé du sujet- Barriers to the transmission of multidrug-resistance conjugative plasmids of the IncC group- Champs scientifiques- Biologie
- Biochimie
- Santé, médecine humaine, vétérinaire
- Mots clés- Bacteria, Multidrug resistance, Plasmids, Conjugation, Salmonella, Vibrio**Description du sujet**:
**Surface exclusion. **Surface exclusion prevents the redundant and futile exchange of a conjugative plasmid between donor cells. Our recent results indicate the existence of such a mechanism in IncC plasmids. The project aims to investigate the mechanism of surface exclusion and its extent to closely and distantly related plasmids. The proteins mediating surface exclusion and the host membrane receptors involved in the phenomenon will be researched and characterized. The student will also investigate whether and how SGI1 can escape surface exclusion mediated by IncC plasmids.

**Entry exclusion. **IncC plasmids also limit the redundant transfer of the same plasmid between donor cells via entry exclusion. This mechanism acts after the contact between partner cells has been established. Entry exclusion blocks DNA transfer by a poorly understood mechanism. This project aims to determine how DNA transfer is inhibited by investigating the interactions between the inner-membrane proteins TraG and EexC that mediate entry exclusion by acting in the donor and recipient cells, respectively.

**How do IncC plasmids resist or evade defence mechanisms encoded by their bacterial host? **IncC plasmids easily circumvent the barriers put in place by their bacterial hosts (CRISPR-Cas, restriction-modification systems) to prevent invasion by exogenous genetic material or bacteriophage attacks. These resistance mechanisms allow IncC plasmids to broaden their host spectrum and establish themselves in a wide variety of bacterial species pathogenic for humans. The study will study these resistance mechanisms, determine their prevalence in related plasmids, and characterize the molecular mechanisms allowing resistance.

**Prise de fonction**:

- 01/05/2023**Nature du financement**:

- Autre financement public**Précisions sur le financement**:

- NSERC- and CIHR-funded scholarship**Présentation établissement et labo d'accueil**:

- Université de SherbrookeLocated in the heart of Estrie (Eastern Townships) in Quebec, the University of Sherbrooke is distinguished by practical learning methods, promising themes propelling its research units, a strong strategy of innovation, partnership and entrepreneurship, green campuses and an incomparable quality of life between rivers and mountains. So many reasons that make it one of the most appreciated universities in Canada by its students.

Our research group is funded by the Canadian Institutes of Health Research (CIHR), the Natural Sciences and Engineering Research Council of Canada (NSERC), as well as by provincial funds from the Fonds de Recherche du Québec (FRQ). The laboratory is equipped for carrying out biosafety level 2 microbiology, molecular biology and biochemistry experiments.

**Site web**:
**Intitulé du doctorat**:

- Doctorat en biologie**Pays d'obtention du doctorat**:

- Canada**Etablissement délivrant le doctorat**:

- Université de SherbrookeThe Université de Sherbrooke values diversity, equality, equity and inclusion in employment within its community and invites all qualified people to apply. We are an inclusive group and encourage individuals of all sexual orientations and gender identities to join us.- 15/03/2023

  • Barriers to The Transmission of

    2 weeks ago

    Sherbrooke, Quebec, Canada Université de Sherbrooke Full time

    Barriers to the transmission of multidrug-resistance conjugative plasmids of the IncC group:Réf- ABG-111116 Sujet de Thèse 13/02/2023 Autre financement public Université de Sherbrooke Lieu de travail Sherbrooke Canada Intitulé du sujet Barriers to the transmission of multidrugresistance conjugative plasmids of the IncC group Champs scientifiques Biologie...

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