Postdoctoral Fellow in Bioinformatics

2 weeks ago

Vancouver, Canada Vancouver Prostate Centre Full time

**Vancouver Prostate Centre**

The Vancouver Prostate Centre (VPC) has an exciting opportunity for a Postdoctoral Fellow interested in pursuing a role in bioinformatics.

**The Vancouver Prostate Centre**

Located in Vancouver, the Vancouver Prostate Centre (VPC) is a leader in life changing breakthroughs in cancer research and patient care. VPC has a large, multi-disciplinary research program that undertakes basic, clinic, and translational research. It is a National Centre of Excellence and a designated Centre of Excellence for Commercialization and Research. It is affiliated with the University of British Columbia and the Vancouver Coastal Health Authority.

At VPC, we provide robust mentorship for those on an academic track to pursue higher education. We also have numerous collaborations with pharmaceutical companies which provides invaluable networking opportunities and the opportunity to gain transferable skillsets for industry positions.

**Position Summary**

Dr. Lucia Nappi and Dr. Martin Gleave lead the GUNS study, a genomic-driven neoadjuvant clinical trial that is currently enrolling patients with localized prostate cancer to receive targeted agents and androgen deprivation therapy on the basis of genomic sequencing of the prostate biopsy. The pre and post-treatment tissue and blood samples will be used for genomics, transcriptomics and epigenomics to identify the molecular drivers of treatment response or resistance to standard and experimental drugs.

**Typical Responsibilities**
- Integrative data analyses of genome sequencing, RNA-sequencing, DNA methylation profiling and ChIPseq data from patients samples to define new treatment paradigms for advanced prostate cancer.
- Specifically, DNA and RNA extracted from both tumor tissue and blood of patients enrolled in clinical trials or research biobank will be analyzed to identify potential biomarkers of therapy response or resistance and for new therapeutic targets discovery.
- Moreover, DNA and RNA from patients-derived xenografts and in vitro prostate cancer models ((e.g. CRISPR-Cas9) will be also available to test new drugs and to confirm molecular pathways involved in treatment response or resistance.

**Decision Making/Level of Accountability/Extent of Authority**

The Postdoctoral Fellow is accountable for the quality and integrity of the research and data, including analyses and interpretation, as well as the effective and efficient management of research projects and deliverables. This position requires innovation, strategic planning, and adaptability. Incorrect decisions or actions may damage the reputation of the laboratory, lead to loss of credibility in this field, and be financially costly.

**Supervision Received**

**Supervision Given**

This position may involve supervision of undergraduate students and clinical data management specialists to accomplish research goals.

**Minimum Qualifications**
- PhD (or equivalent) in bioinformatics, computational biology, biostatistics, computer science and/or the life sciences.
- A strong background in statistics and biology.
- Demonstrable experience managing and analyzing large datasets desired.
- Excellent oral and written communication skills and the ability to perform both self-directed and guided research are required.
- Must demonstrate outstanding personal initiative and the ability to work effectively as part of a team.
- Ability to work effectively and multi-task in a fast-paced and in a multi-disciplinary environment.
- Ability to seek out mentorship within the VPC community.
- Experience in R and/or Python is preferred, with willingness to learn new languages and tools as the field grows.
- This position may involve supervision of undergraduate students and clinical data management specialists to accomplish research goals.

**Application Procedures**
- Covering letter
- Resume

**Benefits**:

- Employee assistance program
- Extended health care

Flexible Language Requirement:

- French not required

Schedule:

- 8 hour shift
- Monday to Friday

Ability to commute/relocate:

- Vancouver, BC V6H 3Z6: reliably commute or plan to relocate before starting work (preferred)

**Education**:

- Post-Doctorate (preferred)

Work Location: In person

Application deadline: 2023-05-05

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