Real World Evidence Associate Director

4 months ago

Mississauga, Canada AstraZeneca Full time

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies.

Oncology is driven by speed. Here you will be backed by leadership and empowered at every level to prioritize and make ambitious moves. Be a daring decision-maker. Speak up and constructively challenge. Powered to take sensible risks based on scientific evidence. Here it’s our scale, agility and passion that makes sure we deliver fast, every time.

The Oncology Real World Evidence R&D team is a new group growing within AstraZeneca. AstraZeneca has a pedigree of experience in Real World Evidence, having developed a coherent strategy to develop and internalize rich data assets the group is now amplifying those investments through a Real World Evidence Data Science capability.

We are looking for a quantitative epidemiologists, bioinformaticians, health informaticians, biomedical data scientists, clinicians/pharmacologists, bio-statisticians or related fields with a strong desire to learn and expand their abilities into the analysis of Real World Evidence (RWE).

The AstraZeneca Oncology R&D RWE group provide expert analysis and interpretation of the complex biomedical data captured in electronic health records, claims data, registries, wearables and epidemiological observations. This important work, which provides a rich window on the complicated realities of patients and diseases, is used to support the drug development process in a variety of ways, including:

- Supporting clinical project teams understand the benefits of RWD and support them in their clinical design
- Developing close connections with biometrics and clinical teams to develop a strategy for RWD use within a drug development program
- Interact with senior stakeholders to ensure the value of RWD is understood and supported within a Research and Development setting
- Analyzing longitudinal health data to characterize patient journeys and outcomes
- Sifting claims and prescription data for use patterns and to support label expansion
- Building predictive models of patient outcomes
- Identifying patient subtypes (e.g. via biomarkers) for possible therapy development
- Building synthetic control arms to support the interpretation of clinical studies
- Development of algorithms for better diagnosis and identification of patients
- Searching for evidence of adverse effects in medical histories
- Estimating the number of eligible patients for clinical trials from databases and literature
- Using federated networks of electronic health records for patient identification and recruitment
- Using real world evidence to support pragmatic and hybrid trial designs
- Partnering with external organizations to generate custom real world datasets

**Minimum Qualifications**:

- Master's degree + 5+ years of relevant experience
- Experience in supporting a multidisciplinary team build a research objective that can be met with RWD
- Health analytics and data mining of routinely collected healthcare data
- Use of statistical and scripting languages such as R, Python and SQL
- Health economics or epidemiology, and quantitative science such as health outcome modelling

**Desirable Skills**
- PhD Degree
- Data science, machine learning and construction of predictive models
- Clinical data standards, medical terminologies and healthcare ontologies
- Experience designing and implementing pragmatic clinical trials
- Knowledge of Oncology and Pharmaceutical development

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