Postdoctoral Research Fellow

4 months ago

Vancouver, Canada University of British Columbia Full time

Academic

Job Category

Faculty Non Bargaining

Job Title

Postdoctoral Research Fellow

Department

de Boer Laboratory | School of Biomedical Engineering | Faculty of Medicine (Carl de Boer)

Posting End Date

September 22, 2024

Note: Applications will be accepted until 11:59 PM on the Posting End Date.

Job End Date

Sept 30, 2025

Salary will be commensurate with qualifications and experience, and may range from $60,000-$80,000 per year.

Postdoctoral Research Fellow (PDF) position in personalized medicine for diseases of gene regulation

At UBC, we believe that attracting and sustaining a diverse workforce is key to the successful pursuit of excellence in research, innovation, and learning for all faculty, staff and students. Our commitment to employment equity helps achieve inclusion and fairness, brings rich diversity to UBC as a workplace, and creates the necessary conditions for a rewarding career.

The Boer lab is a mixed computational/experimental group studying gene regulation using synthetic genomics and machine learning with the aim of having a sufficiently detailed understanding of gene expression that we can design personalized therapeutics to prevent and treat disease.

The Faculties of Medicine and Applied Science have partnered to create the SBME, a new flagship entity at UBC, and a top strategic priority for the University and both Faculties. The SBME is a nucleus for education and training, research, and innovation in biomedical engineering, creating new knowledge, new academic and training programs, and fostering translation and innovation. UBC SBME distinguishes itself by deep training in biology, and engineering science and design, enabling SBME researchers to address the most pressing biomedical challenges of the day. Our SBME faculty conduct research that advances our fundamental understanding of human biology, and yields technologies and therapies that advance our health and wellbeing.

Organizational Status

Individuals will report to Dr. Carl de Boer.

Responsibilities

The responsibilities of this position will depend on the strengths of the incumbent, but may include:

- Optimizing, performing, and analyzing high-throughput chemical screens
- Developing genomics technologies including, reporter assays, DNA synthesis, genome engineering
- Reconstructing gene regulatory networks and performing GRN inference
- Single-cell RNA-seq, perturb-seq, and/or other transcriptomic analysis
- Next generation sequencing and bioinformatics analysis
- Machine learning/AI; making, evaluating, and interpreting models
- Analyzing genetics data (e.g. GWAS, eQTLs), including predicting variant effects, stratifying patients, identifying desired patients for recall
- Designing, synthesizing, and testing regulatory or protein coding DNA sequences
- Analyzing data and presenting the data in reports, publications, and presentations at local and international conferences
- Training and mentoring lab personnel, including supervising a wet lab technician
- Human pluripotent stem cell culture including maintenance, expansion, and characterization
- Cell differentiation and culture
- Genetic engineering of mammalian cells
- Helping to enhance our collaborative and interdisciplinary research environment.
- Contributing to cutting-edge knowledge in the scientific community
- Designing and performing experiments, analyzing results, and presenting findings

Qualifications
- High-throughput chemical screening and hit-to-lead optimization
- Genetics/GWAS/eQTL analysis
- Massive parallel reporter assays
- DNA synthesis technology
- Machine learning for genomics
- Single cell omics (e.g. perturb-seq)
- Genomics technology development
- Gene regulatory network reconstruction
- Functional genomics technologies (e.g. fiber-seq, CUT&Tag, ATAC-seq)

Supervision received

The incumbent will receive supervision directly from Dr. de Boer.

Supervision given

The ideal incumbent will have the opportunity to be the primary supervisor of a technician who will be performing the experimental procedures related to this project. They may also be required to supervise other trainees involved in the research program.

Start date and stipend

The anticipated start date for this position is Oct 1, 2024 or upon a date to be mutually agreed. Salary will be commensurate with qualifications and experience, and may range from $60,000-$80,000 per year.

How to Apply

We respectfully acknowledge that the UBC Vancouver campus is located on the traditional, ancestral, unceded territory of the xʷməθkʷəy̓əm (Musqueam) people.

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