Bioinformatician Ii

**Position: Bioinformatician II**
**Site: MaRS Centre, Toronto**
**Department: Genome Sequence Informatics**
**Reports To: Manager, Genome Interpretation**
**Salary: Commensurate with level of experience**

**Hours: 35 hours/week**
**Status: Full-time, Permanent**

The Bioinformatician will provide support for the management and analysis of next-generation sequencing data and the operation of a high-throughput production sequencing data analysis pipelines in OICR’s 5600+ core HPC computing environment.

Fully vaccinated is defined as having received all of the required doses of a Health Canada approved vaccine and having received the final dose at least 14 days before your employment start date.

To learn more about working at OICR, visit our **career page**.

**The responsibilities include**:

- Developing software to facilitate uptake of clinical sequencing data by interpretation software
- Developing tools/software to evaluate performance and statistical validation of clinical sequencing data
- Perform final stage analysis on next-generation sequencing data of clinical cancer genomes and transcriptomes from sequence information to CAP/CLIA-certified reports
- Continuous interaction with the production development team to ensure that the NG sequencing software pipeline is consistently, reliably, efficiently and correctly processing data
- Ensure that data is managed efficiently, securely, and without loss or corruption through its lifecycle
- Investigating and/or developing cutting-edge bioinformatics software for potential clinical utility and integration within the clinical genomics pipeline (ie. mutation signatures, immune repertoire analysis, single-cell sequencing)
- Prepare clinical reports for sign-off by Canadian College of Medical Geneticist (CCMG) certified Director

**Qualifications**:

- Master’s (MSc) degree or equivalent experience in related discipline, with demonstrated experience in the skill set
- Demonstrated knowledge of cancer genomics
- Demonstrated experience interpreting data generated from best-practice pipelines for analyzing NGS data including variant calling pipelines for WGS/Transcriptome sequencing
- Significant knowledge of NGS data processing tools (samtools, GATK, IGV, etc)
- Proficiency working with large-scale datasets in a Unix environment
- Proficiency with a scripting and/or statistical analysis language is preferred (Python, R)
- Must have excellent communications and interpersonal skills

OICR is a collaborative, not-for-profit research institute accelerating the development of new cancer research discoveries for patients around the world while maximizing the economic benefit of this research for the people of Ontario. We are dedicated professionals who bring expertise to each of our roles. We are looking for individuals who share our values of excellence, innovation, collaboration, impact, responsibility and community.

Launched in December 2005, OICR is an independent institute funded by the Government of Ontario through the Ministry of Colleges and Universities.


**CLOSING DATE: Until Filled**
- The Ontario Institute for Cancer Research thanks all applicants. However, only those under consideration will be contacted._