Principal PK Scientist

Job Category: Clinical Pharmacology and Drug Development

Requisition Number: PRINC002811

• Posted : October 6, 2026
• Full-Time
• Remote

Locations

Showing 1 location

Remote Canada

Description

Everest Clinical Research (\"Everest\") is a full-service contract research organization (CRO) providing a broad range of expertise-based clinical research services to worldwide pharmaceutical, biotechnology, and medical device industries. We serve some of the best-known companies and work with many of the most advanced drugs, biologics, and medical devices in development today.

Everest has been an independent CRO since 2004 with a strong foundation as a statistical and data management center of excellence. Building on this foundation, Everest has successfully developed and established itself as a full-service CRO. Everest’s Corporate headquarters are located in Ontario, Canada and US headquarters in New Jersey, USA, with additional physical offices in Asia and Europe.

Everest is known in the industry for its high-quality deliverables, superior customer service, and flexibility in meeting clients’ needs. A dynamic organization with an entrepreneurial origin, Everest continues to experience exceptional growth and great success.

Quality is our backbone, customer-focus is our tradition, flexibility is our strength…that’s us…that’s Everest.

To drive continued success in this exciting clinical research field, we are seeking committed, skilled, and customer-focused individuals to join our winning team as Principal PK Scientist for our Toronto/Markham, Ontario, Canada on-site location, or remotely from a home-based office anywhere in Canada in accordance with our Work from Home policy.

RESPONSIBILITIES

Scientific Leadership and Strategic Consultation:

Provide strategic clinical pharmacology, pharmacokinetic, pharmacodynamic, and pharmacometric expertise to support clinical trial design, compound development plans, regulatory strategies, and drug development decision‑making.

Independently serve as lead PK/PD scientist on large, complex, or high‑profile development programs.

Provide scientific consultation to Sponsors regarding clinical pharmacology strategy, PK/PD study design, dose selection, exposure‑response analyses, and model‑informed drug development approaches.

Identify potential development risks and propose mitigation strategies related to study design, PK sampling schedules, endpoint selection, population selection, and clinical pharmacology assessments.

Stay current with emerging regulatory expectations, scientific developments, and industry best practices related to clinical pharmacology and pharmacometrics.

Provide technical mentorship, coaching, and scientific guidance to PK Scientists and Senior PK Scientists.

Support onboarding and training initiatives within the Clinical Pharmacology and Drug Development group.

Contribute to the development and maintenance of departmental SOPs, guidance documents, standards, templates, and working practices.

Maintain expertise in clinical pharmacology, pharmacometrics, drug development, regulatory science, and emerging modeling methodologies.

Participate in scientific publications, conference presentations, and external professional activities as appropriate.

Plan and carry out professional development activities

Pharmacometric Modeling and Data Analysis:

Lead, conduct, and oversee advanced compartmental and non‑compartmental analyses, population PK/PD modeling, exposure‑response analyses, disease progression modeling, and model‑informed drug development activities.

Develop and oversee modeling and simulation strategies utilizing WinNonlin®, NLME, Monolix, Simulx, R, and other relevant software platforms.

Generate predictive simulations to support dose selection, study design optimization, and regulatory interactions.

Provide strategic interpretation of PK/PD data and communicate findings to multidisciplinary teams and Sponsors.

Regulatory and Scientific Documentation:

Author and/or provide scientific review of PK Analysis Plans, PK/PD Analysis Plans, Modeling and Simulation Analysis Plans, Clinical Study Reports, Clinical Pharmacology Reports, Investigator's Brochu