Post-doctoral fellow: Synthetic chemistry and cell biology

2 weeks ago

Eastern Ontario, Canada Queen's University Full time

ContextA collaboration between the groups of Dr. Petitjean (Chemistry) and Dr. Mulligan (Sinclair Cancer Research Institute) is exploring a family of small molecules for the selective down-regulation of an important oncogenic proteins, taking advantage of the formation of guanine quadruplexes in their gene promoter.Responsibilities(i) expanding the library of small molecules(ii) improving cellular entry (e.g. via liposomal formulations)(iii) assessing their G4 preference using biophysical methods(iv) cellular study of the most promising small regulatorsQualificationsA robust research expertise in organic synthesis is required. Some experience in molecular or cellular biology and biophysical methods are recommended. Experience with liposomal technology is a plus.Working at the interface between two groups, a strong sense of initiative and strong communication skills are important.EnvironmentThe research environment within Queen’s University is highly multidisciplinary and collaborative. This project bridges the departments of Chemistry and of Pathology & Molecular Medicine.Depending on progress and needs of the project, missions to the following sites may be envisaged: University of Toronto (drug formulation), University of Strasbourg, France (screening of responses in cancer cell lines), and Ecole Polytechnique, Palaiseau, France (advanced biophysics).Professional DevelopmentProfessional Development is available at Queen’s University (Leadership, communication workshops) and through the Ontario Institute for Cancer Research. The Canadian research community offers multiple venues for scientific exposure and networking.This new position is associated with a starting annual salary of CAD 51,000-52,000 plus benefits, for 1 year and a possible extension. It can start as early as February 2026. Candidates are invited to apply to Dr. Petitjean (anne.petitjean@chem.queensu.ca) with a CV and a motivation letter. Except for the built-in LinkedIn filter questions ensuring eligibility, no AI is used in the follow-up and final hiring steps. #J-18808-Ljbffr

  • Post-doctoral fellow: Synthetic chemistry and cell biology

    2 weeks ago

    Eastern Ontario, Canada Queen's University Full time

    Context A collaboration between the groups of Dr. Petitjean (Chemistry) and Dr. Mulligan (Sinclair Cancer Research Institute) is exploring a family of small molecules for the selective down-regulation of an important oncogenic proteins , taking advantage of the formation of guanine quadruplexes in their gene promoter. Responsibilities (i) expanding the...

  • Postdoctoral Fellow: Synthetic Chemistry

    2 weeks ago

    Eastern Ontario, Canada Queen's University Full time

    A leading Canadian university in Kingston is seeking a researcher for a project focused on small molecules aimed at down-regulating oncogenic proteins. The role involves expanding a library of compounds, improving cellular entry, and employing biophysical methods to assess their effectiveness. Ideal candidates have strong expertise in organic synthesis and...

  • Postdoctoral Fellow: Synthetic Chemistry

    2 weeks ago

    Eastern Ontario, Canada Queen's University Full time

    A leading Canadian university in Kingston is seeking a researcher for a project focused on small molecules aimed at down-regulating oncogenic proteins. The role involves expanding a library of compounds, improving cellular entry, and employing biophysical methods to assess their effectiveness. Ideal candidates have strong expertise in organic synthesis and...

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