Sr. Dir., In Vivo Pharmacology

GondolaBio is a clinical-stage biopharmaceutical company focused on developing next-generation therapeutics for genetic diseases. Originally launched as BridgeBioX, a subsidiary of BridgeBio, GondolaBio secured $300M in private financing from external investors in 2024 and became an independent company within the BridgeBio ecosystem. The company aims to leverage cutting-edge biological resea0rch to create breakthrough medicines addressing high unmet needs across multiple therapeutic areas, including neurology, pulmonology, cardiology, nephrology, and endocrinology. Located on the Stanford Life Sciences campus, GondolaBio fosters a unique hybrid environment where top scientists from around the world collaborate with senior leadership and advisors, blending industry expertise with academic innovation. About BridgeBio BridgeBio is a commercial stage biopharmaceutical company founded to discover, create, test, and deliver transformative medicines to treat patients who suffer from genetic diseases and cancers with clear genetic drivers. Our focus on scientific excellence and rapid execution aims to translate today’s discoveries into tomorrow’s medicines. We bridge the gap between remarkable advancements in genetic science in academic institutions and the delivery of meaningful medicines to patients. Founded in 2015, the company built a portfolio of 22+ drug development programs ranging from preclinical to late-stage development in multiple therapeutic areas including precision oncology, cardiology, endocrinology, neurology, pulmonology, renal disease, and genetic dermatology, with three approved drugs. We have U.S. offices in San Francisco, Palo Alto, and Raleigh. We also have international offices in Montreal, Canada, and Switzerland. Who You Are We are seeking a highly motivated scientist to lead preclinical pharmacology work, and bring our research programs in genetic medicine into clinic. The Senior Director of Preclinical Pharmacology will play a critical role in enabling in vivo pharmacology for therapeutics from spanning multiple treatment modalities and therapeutic areas. Candidates must have extensive relevant industrial experience including evidence for scientific leadership in the design and execution of complex studies aimed at nonclinical testing of therapeutically relevant hypotheses in animal models of disease. Candidates should be self-starters, comfortable with autonomy, and embrace opportunities to tackle new problems and challenges as part of a dynamic team in a start-up-like environment Requirements Essential Skills and Function Design and execute on in vivo pharmacology studies across multiple programs in our research portfolio, with goals of IND submission. As part of research leadership team, provide strategy and vision; make decisions that establish objectives for the overall direction or operation of research programs. Mentor internal teams to efficiently to drive projects forward. Preferred Education and Experience Ph.D. in Life Sciences, Pharmacology, Toxicology, or related discipline; strong publication record is a plus. 15+ years of biopharmaceutical industry experience in in vivo pharmacology. Experience in bringing programs into clinic, including supporting IND applications Experience with small molecules and antisense oligopeptides (ASOs) are preferred Experience in neurology is preferred, so are exposure across multiple TAs Strong intellectual curiosity as demonstrated by routine engagement with scientific community and familiarity with literature. Direct experience and willingness to continue design pharmacology study with hands on involvement. Exposure to DMPK modelling and technical and nontechnical writing are highly desirable. Experience in managing technical tasks performed by Contract Research Organizations, as well as contract vivarium. Excellent interpersonal skills and mentorship mindset, with a proven track record of building and mentoring research teams. No matter your role at BridgeBio, successful team members are: Patient Champions, who put patients first and uphold strict ethical standards Entrepreneurial Operators, who drive toward practical solutions and have an ownership mindset Truth Seekers, who are detailed, rational, and humble problem solvers Individuals Who Inspire Excellence in themselves and those around them High-quality executors, who execute against goals and milestones with quality, precision, and speed What We Offer Patient Days, where we are fortunate to hear directly from individuals living with the conditions we are seeking to impact throughout the year and learn how we can improve our efforts A culture inspired by our values: put patients first, think independently, be radically transparent, every minute counts, and let the science speak An unyielding commitment to always putting patients first. A de-centralized model that enables our program teams to focus on advancing science and helping patients. Our affiliate structure is designed to eliminate bureaucracy and put decision-making power in the hands of those closest to the science A place where you own the vision – both for your program and your own career path A collaborative, fast-paced, data-driven environment where we inspire ourselves and each other to always perform at the top of our game Access to learning and development resources to help you get in the best professional shape of your life Robust and market-competitive compensation & benefits package (Base, Performance Bonus, Equity, health, welfare & retirement programs) Flexible PTO Rapid career advancement for strong performers Potential ability to work on multiple BridgeBio Pharma programs across multiple therapeutic areas over time · Partnerships with leading institutions Commitment to Diversity, Equity & Inclusion The base pay range for this position is $255,000 to $285,000 per year. The actual compensation offered will be determined based on a number of job-related factors, including experience, skills, qualifications, and location. A bonus plan and equity will also be offered. #J-18808-Ljbffr