Academic Researcher

3 days ago


Old Toronto, Canada Princess Margaret Cancer Centre Full time

We are seeking an exceptional Postdoctoral Researcher to join our team investigating dependencies associated with clonal hematopoiesis and acute myeloid leukemia and developing innovative therapeutic strategies targeting these conditions. The Chan Laboratory is located at the Princess Margaret Cancer Centre in Toronto, Canada with full access to state-of-the-art facilities in Toronto's Discovery District. The lab employs advanced genetic screening and CRISPR/Cas9 genome editing tools to identify and investigate specific gene dependencies that drive clonal hematopoiesis and acute myeloid leukemia progression in mouse models.

Duties:

  • Design and Conduct Experiments: Develop and execute experimental protocols to investigate the biology of leukemia stem cells and mechanisms of clonal hematopoiesis, using advanced molecular and cellular techniques.
  • Data Analysis and Interpretation: Perform comprehensive data analysis, including bioinformatics and statistical analysis, to interpret experimental results and draw meaningful conclusions.
  • Stem Cell Isolation and Characterization: Isolate and characterize hematopoietic stem cells and leukemia stem cells from primary patient samples or animal models, utilizing techniques such as flow cytometry, cell sorting , and other stem cell assays.
  • Collaborative and Teamwork: Work closely with other researchers, including graduate students and other post-doctoral fellows, to support ongoing projects and foster a collaborative research environment.
  • Literature Review and Research Development: Stay updated on recent literature and advancements in leukemia research, identify new research opportunities, and propose novel hypotheses to explore within the lab's focus area.
  • Manuscript and Grant Writing: Prepare research findings for publication in peer-reviewed journals and contribute to writing grant applications to secure additional funding for research projects.
  • Mentorship and Training: Mentor junior researchers, including graduate and undergraduate students, by providing guidance on experimental design, lab techniques, and data analysis.
  • Presentation of Findings: Present research findings at lab meetings, seminars, and national or international conferences to share progress and gain feedback from the scientific community.

Qualifications:

  • PhD must be obtained within the previous 5 years in molecular biology, genetics, biochemistry, or related field
  • Strong background in cancer biology, particularly hematological malignancies
  • Expertise in molecular biology, genetic screening and genome editing techniques
  • Experience in flow cytometry, tissue culture, or working with animals is an asset
  • Excellent analytical and problem-solving skills
  • Proven track record of scientific publications
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