Associate Director, Quantitative Pharmacology and Pharmacometrics

2 weeks ago


Toronto, Ontario, Canada Merck Full time
Merck Associate Director, Quantitative Pharmacology and Pharmacometrics – Immune/Oncology (Remote) Madison, Wisconsin

We are looking for a skilled scientist to join our Quantitative Pharmacology and Pharmacometrics – Immune/Oncology (QP2-IO) team in the role of Associate Director. The QP2-IO team is part of the Global Clinical Development organization, focusing on drug development aspects related to clinical pharmacology and pharmacometrics of oncology drugs.

Primary Responsibilities:

  • Serve as an expert representative for QP2-IO on Oncology clinical development teams.
  • Frame critical questions for optimizing model-based analyses on programs.
  • Develop and execute model-based analyses including translational PK/PD approaches, population pharmacokinetic models, exposure-response models, clinical trial simulation, disease progression models, quantitative systems pharmacology (QSP) modeling, comparator modeling, to enhance pharmacometrics capabilities.
  • Strategize and execute modeling of tumor size and survival endpoints including proportional hazards models.
  • Maintain a comprehensive understanding of global regulatory expectations for small molecules and biologics in Oncology.

Requirements:

  • Ph.D. with 1-3 years of pharmaceutical drug development experience or Masters/PharmD with 3-5 years of experience.
  • Demonstrated experience in pharmacometrics methods, experimental design, critical data analysis, and statistics.
  • Proficiency in R, NONMEM or similar programming languages.
  • Strong written and verbal communication skills.

If you are a talented scientist seeking a challenging role in a dynamic environment, consider joining us This position is remote, catering to those not within commutable distance to primary sites. Internal applicants must have a minimum of twelve months of service in their current position before applying for new roles.



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