DMPK Senior Scientist

6 days ago

Montréal QC, Canada Congruence Therapeutics Full time

Congruence is currently seeking for an experienced DMPK scientist with proficiency in the design and interpretation of in vitro and preclinical in vivo DMPK studies. Reporting to the Executive Director of DMPK, the successful candidate will work closely with affiliated CROs and internal project teams to support the progression of compounds through hit-to-lead to Development candidate nomination.

About the Responsibilities

  • Communicate and collaborate with CROs for flawless execution of outsourced studies;
  • Review reports to ensure high quality data;
  • Maintenance of database, ADME requests calendars and tracking records;
  • Act as DMPK rep on project team(s) where your main role will be to communicate ADME-PK data and ensure proper interpretation of the results by multidisciplinary team members;
  • As required, perform PK modelling and simulations to inform on dosing scenarios and more advanced PK analysis;
  • Perform human PK parameter predictions to inform selection of human therapeutic dose;

The Ideal Candidate For This Role Will Have

  • B.Sc, MS or Ph.D. degree in Pharmacokinetics, Pharmaceutical Sciences or Chemistry with at least 7 years of industry experience in a biotech/pharma company
  • Strong working knowledge of concepts related to ADME of drugs, pharmacokinetic modeling, and bioanalysis
  • Working knowledge of PK analysis software (e.g., WinNonlin, NONMEM, etc.)
  • Sound understanding of regulatory guidance related to ADME/PK characterization and drug-drug interactions
  • Experience working with external vendors to provide ADME/PK support for drug discovery programs
  • Excellent interpersonal, oral, and written communication skills
  • Track record of successful problem solving and scientific rigor
  • Demonstrated ability to influence and lead others

Attributes That Will Make You Successful At Congruence

  • Passionate and curious
  • Drug hunter mentality driven by the desire to deliver new medicines to underserved patients
  • Excitement for using and creating novel technologies and processes
  • Strong team spirit and interpersonal skills, and interest in working with highly talented individuals in a fast-paced, goal-oriented environment
  • Strong sense of engagement, ownership, accountability and independence

We Offer

  • A meritocracy that is committed to delivering new medicines to underserved patients
  • The opportunity to work innovatively at the interface of the dry lab and wet lab
  • The prospect of getting in on the ground floor and making your mark
  • Highly competitive base compensation and incentive pay
  • Stock options
  • Premium benefits including health, dental, and vision
  • Telehealth
  • Flexible policies
  • Modern labs in a bio-innovation center environment

Congruence is committed to building an outstanding company with a meritocracy of ideas. We encourage applications from talented individuals of all backgrounds, including but not limited to race, ethnicity, religion, gender, sexual orientation, and age. Your application is strictly confidential.

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