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Scientist/Sr. Scientist
4 months ago
Location: Vancouver, BC
Title: Scientist/Senior Scientist
Summary:
EPM is currently partnered up with a trailblazing gene therapy company dedicated to advancing next-generation platform technologies centered on lipid nanoparticles. The company's mission is to ensure the secure and efficient delivery of nucleic acids (RNA), driving breakthroughs in personalized medicine. Leveraging their comprehensive data portfolio, they look to tailor formulations to specific applications and diverse tissue types, empowering precision and efficacy.
This company is committed to translating personalized nucleic acid therapies into tangible clinical solutions, with the goal of treating and preventing a myriad of diseases.
This role reports into the Director of RNA Biology, and the team currently has bandwidth to bring on 2 seasoned research scientists. Your role focus will be centric to designing, executing, analyzing, and making recommendations on their research protocols related to internal and client-based projects.
Responsibilities:
- Execute and troubleshoot new RNA capabilities independently based on RNA group discussions, relevant literature, and input from supervisors.
- Perform experiments and tasks independently to support nucleic acid design, production, and analysis.
- Produce RNA and related products to support the formulation and preclinical teams.
- Assess the purity and identity of synthesized RNA through characterization using advanced methods such as analytical-HPLC/MS or preparative-HPLC, RNA gels, capping efficiency, dsRNA levels, endotoxin assessment, RiboGreen assay, and/or nanodrop quantitation.
- Evaluate mRNA translation performance in vitro and in cells using established cell-free translation assays (CFT) and validated transfection methods with mammalian cell lines, respectively.
- Collaborate with the Formulation and Preclinical Teams to evaluate RNA activity.
- Engages in proactive collaboration and interaction with partners, as well as internal teams, to facilitate the development, characterization, and testing for project advancement.
Qualifications:
- PhD in Biochemistry or Molecular Biology with over 5 years of progressive scientific experience, or equivalent education and experience.
- Comprehensive theoretical and practical expertise in key RNA technologies encompassing design, synthesis, purification, and quantification of RNA.
- Profound understanding of various biochemical and biophysical techniques, including structural biology, nucleotide chemistry, physicochemical properties of RNA, and analytical methods.
- Advanced knowledge in RNA Biology domains, covering transcription, RNA processing and transport, translation, mechanisms of transcriptional/translational control, RNA decay, associated mechanisms, and RNA-protein interaction.
- Demonstrated leadership skills in effectively guiding and mentoring junior team members.
- Proven leadership experience in managing multiple research projects and associated budgets.
- Exceptional organizational abilities, adept time management skills, and adeptness in prioritization.
- Established track record of innovation and contribution through the introduction of novel ideas.
If you are interested in hearing more about this role and your potential fit, please apply in now Additionally, if you have a colleague or friend that might be interested, feel free to share.
