Research Associate – Antibody Lead Optimization

1 day ago

Burnaby, Canada Simon Fraser University Full time

Job Overview:

The Pantophlet Lab at Simon Fraser University (SFU) is seeking a motivated Research Associate to join the PROGENITER project. This full-time role focuses on optimizing and advancing neutralizing antibody (nAb) leads against viral diseases, starting in March 2024.


PROGENITER project is a cutting-edge initiative to advance at least three antibodies into IND-enabling studies by 2027. The project is supported by AI-enabled antibody discovery and includes partnerships with leading companies such as AbCellera, Amgen, and Zymeworks.


Key Responsibilities:

  • Collaborate with PROGENITER team members and external partners to optimize antibody candidates from discovery through lead development.
  • Down-select nAb candidates using immunological and virological assays
  • Enhance nAb leads using biophysical and biochemical techniques.
  • Refine antibody binding and potency through structure-guided approaches.
  • Utilize screening platforms to improve antibody performance and manufacturability.
  • Contribute to multidisciplinary research efforts and support the transition of nAb leads to clinical-grade candidates.
  • Present research findings and assist in preparing scientific publications.


Preferred Qualifications:

  • PhD in Immunology, Biochemistry or a related field
  • Strong experience in antibody engineering/optimization, virological assays and molecular biotechniques.
  • Proficiency in high-throughput screening and lead optimization.
  • Proven ability to work effectively in a collaborative, interdisciplinary environment.
  • Strong organizational skills focused on meeting project milestones.
  • Familiarity with drug development and regulatory processes is a plus.


Application Process:

Interested candidates should submit a single PDF containing:

  •  A cover letter outlining experience in antibody research and lead optimization.
  • A curriculum vitae (CV).
  • Contact information for three professional references, preferably supervisors.


Priority will be given to Canadians and permanent residents.


Why Join Us?

The Pantophlet Lab provides a dynamic and innovative setting dedicated to advancing pandemic preparedness. Be part of our mission to enhance global health through pioneering research in antibody discovery and development.

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