Modeling Scientist

1 month ago

Victoria, Canada Eupraxia Pharmaceuticals Inc. Full time
Eupraxia) is a clinical-stage biotechnology company focused on developing locally delivered, extended-release products that can potentially address therapeutic areas with high unmet medical needs. The Company strives to improve patient benefit and has developed technology that delivers targeted, long-lasting activity with fewer side effects. Diffusphere, a proprietary, polymer-based micro-sphere technology, facilitates targeted drug delivery with an extended duration of effect and offers multiple, highly tuneable PK profiles. The technology can be used with multiple active pharmaceutical ingredients and delivery methods.Eupraxia's lead product candidate, EP-104IAR, recently completed a Phase 2b clinical trial for the treatment of pain due to osteoarthritis of the knee. Eupraxia is also developing a pipeline of later- and earlier-stage long-acting formulations. Potential pipeline indications include candidates for both other inflammatory joint indications and oncology, each designed to improve the activity and tolerability of currently approved drugs. For further details about Eupraxia, please visit the Company's website at www.p>We are looking for people who would like to be part of a fast-paced, growing company that fosters a creative spirit and integrated teamwork and who are eligible to work in Canada or the USA.Eupraxia is dedicated to advancing healthcare through innovation and data-driven decision-making. We are seeking a highly skilled and experienced Data Science and Pharmacokinetic Modeling Scientist to cover a maternity period of not less than 12 months to maintain and evolve our programs designed to deliver appropriate, robust and defensible data in a readily understandable manner. They will also be responsible for preparing and maintaining related documentation for relevant due diligence exercises, ensuring the content is comprehensive and structured to make the most complex issues and analyses accessible to lay personnel. In addition to performing standard pharmacokinetic analyses, this person will be responsible for leveraging advanced inferential tools and pharmacokinetic modeling to drive strategic insights and competitive intelligence.Reports to: Chief Science Officer Perform standard pharmacokinetic analysis of non-clinical and clinical data.Provide expert statistical and data modeling advice in designing and reviewing analysis and reporting plans for pre-clinical and clinical programs.Create models that tie pharmacokinetic data to efficacy and safety endpoints.Interact with regulatory authorities to resolve data and modeling issues relating to the design, analysis and reporting of pre-clinical and clinical studies used in regulatory submissions.Design and implement visualizations to communicate complex data in a clear and actionable manner.Maintain an ongoing comprehensive analysis of developments in the pharmaceutical environment.Provide strategic insights and recommendations based on competitive intelligence to guide and influence the entirety of internal programs.A master’s or PhD in mathematics, statistics, pharmacometrics, data science, or a related field.Proven experience in pharmacokinetic modeling and data visualization, preferably in the pharmaceutical industry.Experience with skills for pharmaceutical formulation development, such as pharmacokinetic modeling, experiment design, and the use of ordinary and partial differential equations for formulation design, is an asset.High proficiency and strong hands-on experience with the programming language R, specifically in relation to creating graphs with ggplot2 and using other packages like plyr to analyze and manipulate data, are essential.Expertise in other programming languages, such as Python, and domain-specific tools, such as NONMEM, is an asset.Strong analytical and problem-solving skills with a creative mindset.Job Types: Full-time, Fixed term contract
Contract length: li>Dental care Disability insurance Monday to Friday Work Location: Hybrid remote in Victoria, BC V8R 5G4 #

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